Evidence map›Paper›PMID 39827053›Full record

ReviewNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2025

Optical approaches for neurocritical care: Toward non-invasive recording of cerebral physiology in acute brain injury.

Austen T Lefebvre, Nicole E Steiner, Carissa L Rodriguez, Joseph P Angelo, Eyal Bar-Kochba, Rohan Mathur, Marek Mirski, David W Blodgett

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Advancing neurocritical care: Bridging molecular mechanisms and physiological monitoring to neurotherapeutics.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Austen T LefebvreDivision of Neurosciences Critical Care, Departments of Neurology and Anesthesiology & Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA. Electronic address: Alefebv3@jh.edu.
Nicole E SteinerJohn Hopkins University Applied Physics Laboratory, Laurel, MD, 20723, USA.
Carissa L RodriguezJohn Hopkins University Applied Physics Laboratory, Laurel, MD, 20723, USA.
Joseph P AngeloJohn Hopkins University Applied Physics Laboratory, Laurel, MD, 20723, USA.
Eyal Bar-KochbaJohn Hopkins University Applied Physics Laboratory, Laurel, MD, 20723, USA.
Rohan MathurDivision of Neurosciences Critical Care, Departments of Neurology and Anesthesiology & Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Marek MirskiDivision of Neurosciences Critical Care, Departments of Neurology and Anesthesiology & Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
David W BlodgettJohn Hopkins University Applied Physics Laboratory, Laurel, MD, 20723, USA.

Funding

Program in Postdoctoral Research Training in AnesthesiologyT32GM075774 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI SAPNA R KUDCHADKAR, Emmett E Whitaker · 2006 to 2026
$8.1M
NIGMS NIH HHS T32 GM075774
6 · The paper itself

Abstract

Acute brain injury (ABI) is a complex disease process that begins with an initial insult followed by secondary injury resulting from disturbances in cerebral physiology. In the metabolically active brain, early recognition of physiologic derangements is critical in enabling clinicians with the insight to adjust therapeutic interventions and reduce risk of ischemia and permanent injury. Current established approaches for monitoring cerebral physiology include the neurologic physical examination, traditional brain imaging such as computed tomography (CT) and magnetic resonance imaging (MRI), electroencephalography (EEG), and bedside modalities such as invasive parenchymal probes and transcranial doppler ultrasound. Diffuse optical spectroscopy (DOS), diffuse correlation spectroscopy (DCS), and optical coherence tomography (OCT) are non-invasive optical techniques that have shown promise in measuring clinically relevant changes in cerebral physiology. These new modalities may offer clinicians significant benefits as they are safe, can be utilized at the point-of-care, and provide continuous measurements. This paper reviews major causes of primary and secondary ABI encountered in neurocritical care units, conventional measures of cerebral physiology during ABI, and emerging non-invasive optical techniques that have significant potential for translation to the bedside.

Indexed as

BrainBrain InjuriesCritical CareHumansTomography, Optical CoherenceAcute brain injuryCerebral physiologyNon-invasive optical recordingOptical monitoring

Identifiers

PMID39827053
PMCPMC11840349

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.