ArticleInternational dental journal2025
The Impact of a Human Bone Morphogenetic Protein-infused Nano-Bone Material Combined With Traditional Chinese Medicine Carthamus tinctorius on the Repair of Oral Bone Defects.
Article in International dental journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe role of human bone morphogenetic protein-infused in combination with traditional Chinese medicine Carthamus tinctorius in repairing oral bone defects (OBD) was evaluated in this work.
methodsAn experiment was conducted on a rat OBD model, where rats were randomly rolled into Groups A, B, and C based on their different treatments. Micro-CT was utilized to measure jaw bone volume fraction (BV/TV) and bone mineral density (BMD) in rats, while a biomechanical testing machine assessed compressive strength of the jaw bone. Cell culture technique was employed to measure the osteoblast proliferation rate (PR), and enzyme-linked immunosorbent assay was utilized to detect levels of alkaline phosphatase (ALP), osteocalcin (OCN), tumour necrosis factor-alpha (TNF-α), and interleukin (IL)-6 in the serum.
resultRats in Groups B and C showed higher jaw bone BV/TV, BMD, compressive strength, osteoblast PR, ALP, and OCN, demonstrating no great differences with Group A (P > .05). TNF-α and IL-6 in Groups B and C were lower in comparison with those in Group A (P > .05). Notably, Groups B and C exhibited statistically obvious differences in jaw bone BV/TV, BMD, osteoblast PR, ALP, OCN, TNF-α, and IL-6 levels (P > .05).
conclusionThe combined application of human bone morphogenetic protein-infused and traditional Chinese medicine C. tinctorius demonstrated positive effects on repair of OBD, reducing inflammatory response and promoting bone tissue repair and formation, thus effectively treating OBD.
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