ArticleJournal of the American Medical Directors Association2025
Moderate-to-Vigorous Physical Activity at any Dose Reduces All-Cause Dementia Risk Regardless of Frailty Status.
Article in Journal of the American Medical Directors Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- A multidomain trial for cognition in women with cardiovascular disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Trial
- Article
- Integrating frailty into decision-making for disease-modifying therapies in Alzheimer's disease: a proposed expert-opinion based approach.The journal of prevention of Alzheimer's disease · 2026Review
- Exercise-Driven NRF2 Activation as a Systemic Neuroprotective Strategy: Integrating Redox Biology, Muscle-Brain Crosstalk, and Therapeutic Targeting in Neurodegeneration.Biochemical genetics · 2026Review
- The landscape of dementia in India: Prevalence, risk factors, and opportunities ahead.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- An exploratory analysis of 24-h movement behaviors in individuals with cancer completing a 12-week resistance exercise intervention.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Association between physical activity levels and motoric cognitive risk syndrome in Chinese older adults.BMC geriatrics · 2026Article
- Exploring Links between Brain Image-Derived Phenotypes and Accelerometer-Measured Physical Activity in the UK Biobank.bioRxiv : the preprint server for biology · 2026Article
- Is the 10-Year Trajectory of Physical Activity Associated With the Incidence of Mild Cognitive Impairment in Older Adults?Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2026Article
- 2025 Advances in Brain Health: Brain Health as Capital for Vascular and Cognitive Resilience.Stroke · 2026Article
- Associations between joint air pollution exposure, mental health, and physical health and dementia incidence in an aging U.S. cohort.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026Article
- Joint trajectories of objective physical function and cognition and risk of incident dementia: a population-based cohort study.Frontiers in psychiatry · 2026Article
- Preferential lactate metabolism in the human brain during exogenous and endogenous hyperlactataemia.The Journal of physiology · 2025Article
- Association between physical activity patterns and the risk of stroke phenotypes: an accelerometer-based prospective cohort study from the UK Biobank.BMC public health · 2025Article
- Accelerometer-based physical activity, air pollution and risk of dementia subtypes: a prospective study using UK biobank.Frontiers in public health · 2025Article
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Authors and funding
13 authors.
Funding
Abstract
objectivesReaching the moderate-to-vigorous physical activity (MVPA) recommendations of 150 min/wk is difficult for older adults, particularly among those living with frailty and its associated risk of dementia. We examined the dose-response relationship between MVPA and dementia risk among at-risk persons living with and without frailty enrolled in the UK Biobank study.
designSurvival analysis within a prospective cohort study. SETTINGS AND
participantsParticipants at risk for all-cause dementia who wore an Axivity AX3 triaxial wrist-worn accelerometer between February 2013 and December 2015.
methodsMVPA was estimated from wrist-worn accelerometry in a subpopulation of the UK Biobank study. A modified version of the physical frailty phenotype was used to define frailty. Associations between MVPA dose (including interactions with frailty) and first-time incident dementia were analyzed using Cox regression models. MVPA was treated continuously and categorically across 5 levels to estimate the dose-response curve. Models were adjusted for demographics, frailty status, and comorbidities.
resultsThis study included 89,667 adults (median age, 63 years; 56% women), with 735 participants developing dementia over an average of 4.4 years. Average weekly MVPA was 126 minutes. Each 30 minutes higher MVPA was associated with a 4% reduction in the risk of all-cause dementia (hazard ratio, 0.96; 95% CI, 0.93-0.99). The hazard ratios for engaging in 0-34.9, 35-69.9, 70-139.9, and ≥140 MVPA minutes per week were 0.59, 0.40, 0.37, and 0.31, respectively (P < .05 for all) compared with 0 MVPA minutes per week. All associations were similar across frailty status (interaction P for all models > .21). CONCLUSIONS AND IMPLICATIONS: Our results suggest engaging in any additional amount of MVPA reduces dementia risk, with the highest benefit appearing among individuals with no MVPA. These associations are not substantially modified by frailty status.
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