Evidence map›Paper›PMID 39826773›Full record

ArticleNeuroImage2025

Lifespan cardiometabolic exposures are associated with midlife white matter microstructure: The Bogalusa Heart Study.

Reagan Dugan, Sreekrishna Ramakrishnapillai, Julia St Amant, Kori Murray, Kevin McKlveen, Maryam Naseri, Kaitlyn Madden, Lydia Bazzano, Owen Carmichael

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Reagan DuganDepartment of Physics & Astronomy, Louisiana State University, 202 Nicholson Hall, Baton Rouge, LA, 70803, USA; Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA. Electronic address: reagan.dugan@pbrc.edu.
Sreekrishna RamakrishnapillaiDepartment of Neurological Surgery, University of Pittsburgh, 200 Lothrop St suite b-400, Pittsburgh, PA, 15213, USA.
Julia St AmantPennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA.
Kori MurrayPennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA.
Kevin McKlveenPennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA.
Maryam NaseriDepartment of Physics & Astronomy, Louisiana State University, 202 Nicholson Hall, Baton Rouge, LA, 70803, USA; Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA.
Kaitlyn MaddenPennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA.
Lydia BazzanoDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, 1440 Canal Street, Suite 2000, New Orleans, LA, 70112, USA.
Owen CarmichaelPennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA.

Funding

I3C DECADE: Disparities and Equity in Childhood Cardiovascular Exposures and Alzheimer's DementiaR01AG077497 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI BAZZANO, LYDIA, CARMICHAEL, OWEN T. · 2022 to 2025
$11.9M
Lifespan Cardiovascular Risk Exposures and Alzheimer-related brain health: Bogalusa Heart StudyRF1AG041200 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI BAZZANO, LYDIA, CARMICHAEL, OWEN T. · 2019 to 2022
$4.2M
Supplemental Funding Request for RF1 AG062309 Early life glycemic status and Alzheimer's disease neuroimaging markers in middle age: the Bogalusa Heart StudyR01AG062309 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI BAZZANO, LYDIA, CARMICHAEL, OWEN T. · 2019 to 2023
$3.9M
Early Life Cardiovascular Disease Risk Factors, Epigenetic Age Acceleration, and Alzheimer's Disease Related Brain HealthR01AG077000 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Lydia Bazzano, OWEN T. CARMICHAEL · 2022 to 2026
$3.6M
The Role of Vascular Aging in Cognitive and Physical Function - Diversity SupplementR01AG041200 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI BAZZANO, LYDIA · 2012 to 2017
$2.9M
Reproductive history and later-life brain health: The Bogalusa Heart StudyRF1AG075769 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI HARVILLE, EMILY WHEELER · 2023 to 2023
$2.3M
NIA NIH HHS R01 AG041200NIA NIH HHS R01 AG062309NIA NIH HHS R01 AG077000NIA NIH HHS R01 AG077497NIA NIH HHS RF1 AG041200NIA NIH HHS RF1 AG075769
6 · The paper itself

Abstract

introductionCompartment model analysis of diffusion MRI data provides unique information on the microstructural properties of white matter. However, studies relating compartment model microstructural measures to longitudinal cardiometabolic health data are rare.

methods130 cognitively healthy participants in the Bogalusa Heart Study completed diffusion MRI scans. Compartment model analysis was performed, and summary metrics were measured in organized and diffuse white matter. Multiple linear regression models were used to relate the white matter microstructure metrics to demographics and cardiometabolic risk factors.

resultsIn both organized and diffuse white matter, age was associated with worse diffusion metrics, women had better diffusion metrics than men, and African American participants had worse diffusion metrics compared to White participants. Greater blood pressure in pre-adulthood was associated with worse diffusion metrics in midlife. DISCUSSION: Summary metrics from compartment model analyses of diffusion MRI data were associated cardiometabolic risk factors from youth to midlife as well as demographic factors.

Indexed as

Cardiometabolic Risk FactorsWhite MatterAdolescentAdultAgedBlack or African AmericanCardiovascular DiseasesDiffusion Magnetic Resonance ImagingFemaleHumansLongitudinal StudiesLouisianaMaleMiddle AgedWhiteYoung AdultBlood pressurecardiometabolicCompartment modelDiffusion MRIMicrostructureNeurite densityWhite matter

Identifiers

PMID39826773
PMCPMC13480460

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.