ArticleJournal of molecular biology2025
Disordered Regions of Condensate-promoting Proteins Have Distinct Molecular Signatures Associated with Cellular Function.
Article in Journal of molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Adhesion-derived condensates control component availability to regulate adhesion dynamics.Nature communications · 2026Article
- A composition-matching algorithm, MatchIDR, identifies prion-like domains that localize to stress granules.Protein science : a publication of the Protein Society · 2026Article
- Density transitions in the regulation of transcription.Molecular cell · 2026Review
- Allostery in Biomolecular Condensates.Journal of molecular biology · 2026Review
- Molecular grammars of predicted intrinsically disordered regions that span the human proteome.Cell · 2026Article
- Sequence-based prediction of condensate composition reveals that specificity can emerge from multivalent interactions among disordered regions.Communications chemistry · 2025Article
- Beyond peptide targeting sequences: machine learning of cellular condensate localization.Cell research · 2025Article
- Engineering a serum response factor superactivator of smooth muscle gene expression with a condensate-forming domain.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Agrochemical innovation for crop health: moving forward through dynamic disorder.Frontiers in plant science · 2025Article
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2 authors.
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Abstract
Disordered regions of proteins play crucial roles in cellular functions through diverse mechanisms. Some disordered regions function by promoting the formation of biomolecular condensates through dynamic multivalent interactions. While many have assumed that interactions among these condensate-promoting disordered regions are non-specific, recent studies have shown that distinct sequence compositions and patterning lead to specific condensate compositions associated with cellular function. Despite in-depth characterization of several key examples, the full chemical diversity of condensate-promoting disordered regions has not been surveyed. Here, we define a list of disordered regions of condensate-promoting proteins to survey the relationship between sequence and function. We find that these disordered regions show amino acid biases associated with different cellular functions. These amino acid biases are evolutionarily conserved in the absence of positional sequence conservation. Overall, our analysis highlights the relationship between sequence features and function for condensate-promoting disordered regions. This analysis suggests that molecular signatures encoded within disordered regions could impart functional specificity.
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