ArticleParkinsonism & related disorders2025
Longitudinal assessment of white matter alterations in progressive supranuclear palsy variants using diffusion tractography.
Article in Parkinsonism & related disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Longitudinal Videofluorographic Dysphagia Measures in Progressive Supranuclear Palsy.Movement disorders clinical practice · 2026Article
- Unilateral inferior olivary hypertrophy in a patient with primary progressive apraxia of speech.Neuroimage. Reports · 2026Article
- Paired regional complementarity in diffusion MRI reveals disease-specific microstructural profiles in PD, MSA, and PSP: a feasibility study.Scientific reports · 2026Article
- Editorial: Advancing neurodegenerative disease biomarkers: the role of neuroimaging in TDP-43 and tau proteinopathies.Frontiers in neuroscience · 2026Article
- Looking into Abnormal Co-Expressions of Tau and TDP-43 in the Realm of Mixed Dementia Types: A Double-Punch Scenario.Brain sciences · 2025Review
- Tongue strength in progressive supranuclear palsy.Parkinsonism & related disorders · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
introductionWhite matter (WM) tract degeneration is a characteristic feature of progressive supranuclear palsy (PSP), with longitudinal changes observed in PSP-Richardson's syndrome (PSP-RS). Little, however, is known about the other PSP variants. We assessed cross-sectional and longitudinal WM degeneration across PSP variants using diffusion tractography.
methodsForty-eight PSP patients were recruited by the Neurodegenerative Research Group, Mayo Clinic, and underwent two diffusion MRI, 1-year apart. We measured fractional anisotropy and mean diffusivity from eight WM tracts reconstructed using deterministic tractography. Baseline and rates of change were compared across PSP variants grouped into PSP-RS, PSP-cortical, and PSP-subcortical, and correlated with clinical disease severity.
resultsPSP-RS, PSP-cortical and PSP-subcortical showed overlapping but distinct baseline patterns of WM alterations. Longitudinally, faster rates of degeneration were observed in the superior cerebellar peduncle (SCP) and dentatorubrothalamic tract (DRTT) in all groups compared to controls. In PSP-RS, the anterior thalamic radiation also showed faster rates of degeneration compared to controls. PSP-cortical had faster rates of degeneration in many WM tracts compared to controls and other PSP groups, including body of corpus callosum, superior thalamic radiation, superior corticostriatal tract, superior longitudinal fasciculus, and frontal aslant tract. Progression in the PSP-subcortical group was limited to SCP and DRTT. Greater rates of degeneration in the corpus callosum and SCP correlated with worsening disease severity.
conclusionsDifferent progression patterns of WM degeneration characterize the PSP variants, although degeneration of the SCP is a common feature and could be a useful potential biomarker for clinical treatment trials in PSP.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.