Evidence map›Paper›PMID 39826273›Full record

ArticleBiosensors & bioelectronics2025

CIMNE-CRISPR: A novel amplification-free diagnostic for rapid early detection of African Swine Fever Virus.

Tathagata Pal, Zilong Liu, Juhong Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biosensors & bioelectronics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tathagata PalDepartment of Bioengineering, University of California Riverside, Riverside, CA, 92521, USA. Electronic address: prameyo@gmail.com.
Zilong LiuDepartment of Bioengineering, University of California Riverside, Riverside, CA, 92521, USA.
Juhong ChenDepartment of Bioengineering, University of California Riverside, Riverside, CA, 92521, USA. Electronic address: jchen@ucr.edu.

Funding

Novel Approaches to detect and treat sepsisR35GM147069 · NIGMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI Juhong Chen · 2022 to 2026
$2.0M
NIGMS NIH HHS R35 GM147069
6 · The paper itself

Abstract

African Swine Fever Virus (ASFV) is a highly contagious pathogen with nearly 100% mortality in swine, causing severe global economic loss. Current detection methods rely on nucleic acid amplification, which requires specialized equipment and skilled operators, limiting accessibility in resource-constrained settings. To address these challenges, we developed the Covalently Immobilized Magnetic Nanoparticles Enhanced CRISPR (CIMNE-CRISPR) system. This amplification-free diagnostic system seamlessly combines target recognition, sequence-specific enrichment, and signal generation. This approach uses covalent immobilization of CRISPR-LbCas12a-crRNA complexes on Fe

Indexed as

African Swine FeverAfrican Swine Fever VirusBiosensing TechniquesDNA, ViralAnimalsCRISPR-Cas SystemsLimit of DetectionMagnetite NanoparticlesNucleic Acid Amplification TechniquesReproducibility of ResultsSilicon DioxideSwineDNA, ViralMagnetite NanoparticlesSilicon DioxideAmplification-freeASFVCovalent immobilizationCRISPR/LbCas12aDiagnosticMagnetic nanoparticles

Identifiers

PMID39826273
PMCPMC11809620

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.