Evidence map›Paper›PMID 39826078›Full record

ArticlePhotochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology2025

Unravelling the modes of phototoxicity of NIR absorbing chlorophyll derivative in cancer cells under normoxic and hypoxic conditions.

Sucharita Chatterjee, Alok Dube, Shovan Kumar Majumder

Abstract read
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In one paragraph

Article in Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sucharita ChatterjeeHomi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai, 400094, India.
Alok DubeHomi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai, 400094, India. okdube@rrcat.gov.in.ORCID http://orcid.org/0000-0001-7664-4492
Shovan Kumar MajumderHomi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai, 400094, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The efficacy of photodynamic treatment (PDT) against deep-seated tumor is hindered by low penetration depth of light as well as hypoxic conditions which prevails in tumor. To overcome this limitation, Near-infrared (NIR) absorbing photosensitizers have been investigated actively. In the present study we evaluated the PDT efficacy of an NIR absorbing chlorophyll derivative 'Cycloimide Purpurin-18 (CIPp-18)' in Human Breast carcinoma (MCF-7) and cervical adenocarcinoma (Hela) cells under normoxic and hypoxic conditions. PDT with CIPp-18 (2.0 µM, 3 h) and NIR light (700 ± 25 nm, 0.36-1.4 J /cm

Indexed as

Antineoplastic AgentsChlorophyllInfrared RaysPhotosensitizing AgentsCell HypoxiaCell SurvivalDose-Response Relationship, DrugDrug Screening Assays, AntitumorHeLa CellsHumansMCF-7 CellsMolecular StructurePhotochemotherapyReactive Oxygen SpeciesSinglet OxygenAntineoplastic AgentsChlorophyllPhotosensitizing AgentsReactive Oxygen SpeciesSinglet OxygenCellular hypoxiaChlorophyll derivativeMembrane localizationNear-infrared photosensitizerPhotodynamic damage

Identifiers

PMID39826078

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.