Evidence map›Paper›PMID 39826020›Full record

ArticleMolecular biology reports2025

Interleukin 1 receptor associated kinase 1 gene polymorphism association with risk of rheumatological diseases in Egyptian population.

Noha A Doudar, Rasha Khattab, Eman Abdou Qurany, Hoda Ramadan Reyad, Noha Mostafa

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Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Noha A DoudarClinical and Chemical Pathology Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt. Noha_ad@hotmail.com.
Rasha KhattabClinical and Chemical Pathology Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.
Eman Abdou QuranyPediatric Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.
Hoda Ramadan ReyadMedical Biochemistry Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.
Noha MostafaPediatric Rheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInterleukin-1 receptor-associated kinase1 (IRAK1) plays a considerable role in the inflammatory signaling pathway. The current study aimed to identify any association between (rs1059703) single nucleotide polymorphism (SNP) and vulnerability to rheumatological diseases in the pediatric and adult Egyptian population. PATIENTS AND

methodsThe current study included four patient groups: adult Systemic lupus erythematosus (SLE), Rheumatoid arthritis (RA), juvenile systemic lupus erythematosus (JSLE), and juvenile idiopathic arthritis (JIA). Two healthy matched age and sex groups were included as controls. Genotypes of IRAK1 (rs1059703) SNP in patients and controls were determined using the TaqMan allelic discrimination method.

resultsThe frequency of AA homozygous genotype and allele A of IRAK1 (rs1059703) SNP is higher in adult SLE patients compared to adult healthy controls (p-value < 0.005). No similar association was detected regarding RA, JSLE, or JIA. However, JSLE patients carrying the A allele have a higher SLE International Collaborating Clinics (SLICC) damage index (SDI) SDI score and a higher stage of renal biopsy than those carrying the G allele (p-value < 0.005).

conclusionsCarriers of the A allele and its homozygous genotype of rs1059703 SNP are more prone to develop SLE in adult life and to have a more severe form of the disease in children in Egypt. No significant association was detected between this SNP and RA or JIA.

Indexed as

Interleukin-1 Receptor-Associated KinasesRheumatic DiseasesAdolescentAdultAllelesArthritis, JuvenileArthritis, RheumatoidCase-Control StudiesChildEgyptFemaleGene FrequencyGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHumansInterleukin-1 Receptor-Associated KinasesIRAK1 protein, humanAllelic discriminationIRAK1Juvenile idiopathic arthritisSystemic lupus erythematosus

Identifiers

PMID39826020

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.