Evidence map›Paper›PMID 39826019›Full record

ReviewTopics in current chemistry (Cham)2025

Recent Advances in Radical Coupling Reactions Directly Involving Bicyclo[1.1.1]pentane (BCP).

Jiayan Jin, Huimin Yang, Huan Xiang, Yue Lu, Yang Ye

Abstract readReview
PubMed Publisher
In one paragraph

Review in Topics in current chemistry (Cham), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jiayan JinSchool of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, Zhejiang, People's Republic of China.
Huimin YangSchool of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, Zhejiang, People's Republic of China.
Huan XiangSchool of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, Zhejiang, People's Republic of China.
Yue LuSchool of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, Zhejiang, People's Republic of China.
Yang YeSchool of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, Zhejiang, People's Republic of China. yangye@hznu.edu.cn.ORCID http://orcid.org/0000-0001-5279-8104

Funding

Department of Education of Zhejiang Province Y202351674Hangzhou Normal University 2021QDL042Medical Science and Technology Project of Zhejiang Province 2023RC249, 2024KY237Zhejiang Provincial Xinmiao Talents Program 2024R426A050
6 · The paper itself

Abstract

BCP (bicyclo[1.1.1]pentane) is an ideal saturated carbon bioisostere, instead of the traditional benzene group, which has been extensively developed. As a novel building block, BCP could be directly involved in a variety of synthetic methods and widely used in the last-stage modification of drugs, attracting much attention from organic chemists and pharmacists. Radical-type cross-coupling reactions involving BCP enable the simultaneous formation of multiple chemical bonds (e.g., C-C, C-N, C-B, C-S, and C-Si) through metal catalysis, photocatalysis, metal-photo synergistic catalysis, and other catalytic systems. Various radical precursors have been explored, facilitating cross-coupling reactions that directly incorporate BCP. This review highlights these state-of-the-art radical couplings of BCP since 2017, organized by reaction components with emphasis on the scope of substrates, reaction mechanisms, and synthetic applications.

Indexed as

Bridged Bicyclo CompoundsPentanesCatalysisFree RadicalsMolecular StructureBridged Bicyclo CompoundsFree RadicalsPentanesBCPCross-couplingElectrophileMulticomponentRadical

Identifiers

PMID39826019

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.