Evidence map›Paper›PMID 39826012›Full record

ArticleJournal of endocrinological investigation2025

Screening of primary aldosteronism and pheochromocytoma among patients with hypertension: an Italian nationwide survey.

Silvia Monticone, Jessica Goi, Jacopo Burrello, Guido Di Dalmazi, Arrigo F G Cicero, Costantino Mancusi, Elena Coletti Moia, Guido Iaccarino, Franco Veglio, Claudio Borghi and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of endocrinological investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. The role of interviewing in endocrine practice.Journal of endocrinological investigation · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Silvia MonticoneDivision of Internal Medicine 4 and Hypertension Unit, Department of Medical Sciences, University of Torino, Torino, Italy. silvia.monticone@unito.it.ORCID http://orcid.org/0000-0002-7322-2005
Jessica GoiDivision of Internal Medicine 4 and Hypertension Unit, Department of Medical Sciences, University of Torino, Torino, Italy.
Jacopo BurrelloDivision of Internal Medicine 4 and Hypertension Unit, Department of Medical Sciences, University of Torino, Torino, Italy.
Guido Di DalmaziDivision of Endocrinology and Diabetes Prevention and Care, IRCCS Azienda Ospedaliero- Universitaria di Bologna, Bologna, Italy.
Arrigo F G CiceroHypertension and Cardiovascular Risk Research Unit, Medical and Surgery Sciences Department, Alma Mater Studiorum University of Bologna, Bologna, Italy.
Costantino MancusiDepartment of Advanced Biomedical Sciences, Federico II University of Naples, Via S. Pansini 5, 18, Napoli, 80131, Italy.
Elena Coletti MoiaARCA (Associazioni Regionali Cardiologi Ambulatoriali) Piemonte, Turin, Italy.
Guido IaccarinoDepartment of Advanced Biomedical Sciences, Federico II University of Naples, Via S. Pansini 5, 18, Napoli, 80131, Italy.
Franco VeglioDivision of Internal Medicine 4 and Hypertension Unit, Department of Medical Sciences, University of Torino, Torino, Italy.
Claudio BorghiHypertension and Cardiovascular Risk Research Unit, Medical and Surgery Sciences Department, Alma Mater Studiorum University of Bologna, Bologna, Italy.
Maria L MuiesanDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Claudio FerriDepartment of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila AQ, Italy.
Paolo MulateroDivision of Internal Medicine 4 and Hypertension Unit, Department of Medical Sciences, University of Torino, Torino, Italy.
Italian Society of Arterial Hypertension (SIIA)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe delayed or missed diagnosis of secondary hypertension contributes to the poor blood pressure control worldwide. This study aimed to assess the diagnostic approach to primary aldosteronism (PA) and pheochromocytoma (PHEO) among Italian centers associated to European and Italian Societies of Hypertension.

methodsBetween July and December 2023, a 10-items questionnaire was administered to experts from 82 centers of 14 Italian regions and to cardiologists from the ARCA (Associazioni Regionali Cardiologi Ambulatoriali) Piemonte. Results were stratified for geographical area, specialty, and center category (excellence vs. non-excellence centers).

resultsEach center diagnosed an average of 2 cases of PA and 0.2 cases of PHEO annually, with higher figures in excellence centers. PA screening is performed mainly in patients with resistant hypertension (73.2%) or hypertension and spontaneous hypokalemia (84.1%), while only 17.1% and 35.4% of centers screen patients with grade 2-3 hypertension. Screening rate is lower for cardiologists compared to other specialists. The main barriers to wider testing were challenges in interpreting the aldosterone/renin ratio under interfering medications and switching to non-interfering drugs. Clinical scores to predict the likelihood of PA and the definition of Standard Operating Procedures were identified as potential tools to boost screening rates. Testing for PHEO was mostly conducted in patients with typical symptoms (75.6%) and/or hypertensive crisis (74.4%). Only 37.8% of centers screened all patients with adrenal incidentaloma.

conclusionThis study highlights significant gaps in the screening and diagnosis of PA and PHEO across Italian centers and underscores the need for widespread and standardized diagnostic protocols.

Indexed as

Adrenal Gland NeoplasmsHyperaldosteronismHypertensionMass ScreeningPheochromocytomaFemaleHumansItalyMaleMiddle AgedSurveys and QuestionnairesAldosterone to renin ratioPheochromocytomaPrimary aldosteronismSecondary hypertension

Identifiers

PMID39826012
PMCPMC12049289

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.