Evidence map›Paper›PMID 39825985›Full record

ArticleMolecular diversity2025

Design, synthesis, and in vitro antitumor evaluation of novel benzimidazole acylhydrazone derivatives.

Lihui Shao, Nianlin Feng, Yue Zhou, Chengpeng Li, Danping Chen, Chenchen Li, Xiang Zhou, Zhurui Li, Zhenchao Wang

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular diversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lihui Shao *State Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang, Guizhou, 550025, People's Republic of China.
Nianlin Feng *College of Pharmacy, Guizhou Engineering Laboratory for Synthetic Drugs, Guizhou University, Guiyang, Guizhou, 550025, People's Republic of China.
Yue ZhouCollege of Pharmacy, Guizhou Engineering Laboratory for Synthetic Drugs, Guizhou University, Guiyang, Guizhou, 550025, People's Republic of China.
Chengpeng LiCollege of Pharmacy, Guizhou Engineering Laboratory for Synthetic Drugs, Guizhou University, Guiyang, Guizhou, 550025, People's Republic of China.
Danping ChenCollege of Pharmacy, Guizhou Engineering Laboratory for Synthetic Drugs, Guizhou University, Guiyang, Guizhou, 550025, People's Republic of China.
Chenchen LiCollege of Pharmacy, Guizhou Engineering Laboratory for Synthetic Drugs, Guizhou University, Guiyang, Guizhou, 550025, People's Republic of China.
Xiang ZhouState Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang, Guizhou, 550025, People's Republic of China.
Zhurui LiCollege of Pharmacy, Guizhou Engineering Laboratory for Synthetic Drugs, Guizhou University, Guiyang, Guizhou, 550025, People's Republic of China. 1056878529@qq.com.
Zhenchao WangState Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang, Guizhou, 550025, People's Republic of China. zcwang@gzu.edu.cn.

Funding

Guizhou Provincial Foundation for Excellent Scholars Program GCC[2023]072Guizhou Provincial Young Science and Technology Talents Development Project KY[2022]146National Key Research and Development Program of China 2023YFD1400400National Natural Science Foundation of China 32360689Natural Science Foundation of Guizhou Province ZZK[2021]034, ZK[2022]073
6 · The paper itself

Abstract

This study focuses on the design, synthesis, and evaluation of benzimidazole derivatives for their anti-tumor activity against A549 and PC-3 cells. Initial screening using the MTT assay identified compound 5m as the most potent inhibitor of A549 cells with an IC

Indexed as

Antineoplastic AgentsBenzimidazolesDrug DesignHydrazonesA549 CellsApoptosisCell Line, TumorCell MovementCell ProliferationDrug Screening Assays, AntitumorHumansMembrane Potential, MitochondrialReactive Oxygen SpeciesStructure-Activity RelationshipAntineoplastic AgentsBenzimidazolesHydrazonesReactive Oxygen SpeciesA549ApoptosisBenzimidazole derivativeCell cycle

Identifiers

PMID39825985

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.