ArticleVeterinary research communications2025
Therapeutic potential of Bacillus-derived lipopeptides in controlling enteropathogens and modulating immune responses to mitigate post-weaning diarrhea in swine.
Article in Veterinary research communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- DietaryAnimals : an open access journal from MDPI · 2026Article
- Lipopeptide Engineering: From Natural Origins to Rational Design Against Antimicrobial Resistance.Antibiotics (Basel, Switzerland) · 2026Review
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Authors and funding
5 authors.
Funding
Abstract
Post-weaning diarrhea (PWD) is a major concern for pig producers, as stress and early weaning increase susceptibility to enteropathogens like enterotoxigenic Escherichia coli (ETEC) and Salmonella enterica subsp. enterica serovar Typhimurium (S. Typhimurium). This study explores the immunomodulatory and antimicrobial properties of lipopeptide extracts (LPEs) from Bacillus strains which contain surfactin (SF) - an immunomodulatory lipopeptide - and their potential in mitigating PWD. Pre-incubation with LPEs from B. subtilis TC12, containing 1, 40 and 60 µg/ml SF, stimulated TNF-α production significantly (p < 0.05) in LPS-challenged RAW 264.7 cells. In contrast, B. velezensis MFF 2.2 LPE, containing 0.1 and 1 µg/ml SF, reduced TNF-α production by macrophages after LPS-challenge. The production of IFN-γ by these cells was not affected by pre-incubation with any of the extracts. On the other hand, all treatments significantly decreased (p < 0.05) IL-10 production. LPEs significantly reduced (p < 0.05) NO production; however, neither TC12 nor MFF 2.2 LPEs affected macrophage phagocytic activity or bactericidal capacity and, in addition, LPEs showed bacteriostatic activity towards S. Typhimurium and ETEC. Also, LPEs did not affect RAW 264.7 viability (> 90%) in concentrations up to 60 µg/ml SF for TC 12 and 1 µg/ml for MFF 2.2. These findings suggest that LPEs from native Bacillus possess immunomodulatory and antimicrobial properties, which could help control inflammation and inhibit pathogen growth during piglet weaning. According to preliminary in vivo studies, LPEs might offer a promising alternative to reduce antibiotic usage in pig husbandry.
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Registered trials
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