Evidence map›Paper›PMID 39825938›Full record

ArticlePlant foods for human nutrition (Dordrecht, Netherlands)2025

Pro-Arg, The Potential Anti-Diabetes Peptide, Screened from Almond by In-Silico Analysis.

Xin Gu, Zhihui Cong, Di Li, Yakun Hou, Yu Fu, Bimal Chitrakar, Die Wei, Meng Xi, Tao Gao

Abstract read
PubMed Publisher
In one paragraph

Article in Plant foods for human nutrition (Dordrecht, Netherlands), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xin Gu *College of Biology and Food Engineering, Chongqing Three Gorges University, Chongqing, 404100, China.
Zhihui Cong *College of Biology and Food Engineering, Chongqing Three Gorges University, Chongqing, 404100, China.
Di LiCollege of Biology and Food Engineering, Chongqing Three Gorges University, Chongqing, 404100, China.
Yakun HouCollege of Food Science and Technology, Hebei Agricultural University, Baoding, 071000, China.
Yu FuCollege of Food Science, Southwest University, Chongqing, 400715, China.
Bimal ChitrakarCollege of Food Science and Technology, Hebei Agricultural University, Baoding, 071000, China.
Die WeiCollege of Biology and Food Engineering, Chongqing Three Gorges University, Chongqing, 404100, China.
Meng XiCollege of Biology and Food Engineering, Chongqing Three Gorges University, Chongqing, 404100, China.
Tao GaoCollege of Biology and Food Engineering, Chongqing Three Gorges University, Chongqing, 404100, China. gaotao2020@126.com.

Funding

Science and Technology Research Program of the Chongqing Municipal Education Commission KJQN202301255
6 · The paper itself

Abstract

Insulin resistance was considered to be the most important clinical phenotype of type 2 diabetes (T2DM). Almond is a widely-consumed nut and long-term intake was beneficial to alleviating insulin resistance in patients with T2DM. Hence, screening of anti-diabetic peptides from almond proteins was feasible based on the effectiveness of peptides in the treatment of T2DM. Pro-Arg (PR), a potential anti-diabetic peptide screened from almonds proteins using in-silico technology and cell experiment, upregulated the phosphorylation levels of IRS1, PI3K, AKT, and translocation of GLUT4, and showed potential to target AKT1 in molecular simulation, suggesting PR mediated the activation of IRS1/PI3K/AKT/GLUT4 signaling pathway by targeting AKT1 to alleviate insulin resistance. Consequently, PR was the potential anti-diabetes peptide from almond proteins and showed the potential application as a candidate drug for alleviating T2DM.

Indexed as

Diabetes Mellitus, Type 2Hypoglycemic AgentsPeptidesPrunus dulcisComputer SimulationGlucose Transporter Type 4HumansInsulin Receptor Substrate ProteinsInsulin ResistanceNutsPhosphatidylinositol 3-KinasesPhosphorylationPlant ProteinsProto-Oncogene Proteins c-aktSignal TransductionGlucose Transporter Type 4Hypoglycemic AgentsInsulin Receptor Substrate ProteinsIRS1 protein, humanPeptidesPhosphatidylinositol 3-KinasesPlant ProteinsProto-Oncogene Proteins c-aktAlmondAnti-diabetic peptidesIn-silico analysis

Identifiers

PMID39825938

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.