Evidence map›Paper›PMID 39825936›Full record

ArticleEuropean child & adolescent psychiatry2025

Disentangling the neural underpinnings of response inhibition in disruptive behavior and co-occurring ADHD.

Gülhan Saraçaydın, Daan van Rooij, Renee Kleine-Deters, Marieke Messchendorp, Jilly Naaijen, María José Penzol, Mireia Rosa, Pascal-M Aggensteiner, Sarah Baumeister, Nathalie Holz and 15 more

Abstract read
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In one paragraph

Article in European child & adolescent psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. [The microbiota-gut-brain axis in childhood attention-deficit/hyperactivity disorder: mechanisms and therapeutic advances].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Gülhan SaraçaydınDepartment of Child and Adolescent Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Daan van RooijDepartment of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
Renee Kleine-DetersDepartment of Child and Adolescent Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Marieke MesschendorpDepartment of Child and Adolescent Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Jilly NaaijenDepartment of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
María José PenzolChild and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, Madrid, Spain.
Mireia RosaDepartment of Child and Adolescent Psychiatry and Psychology, Clínic Institute of Neurosciences, Hospital Clínic de Barcelona, IDIBAPS, Barcelona, Spain.
Pascal-M AggensteinerDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Sarah BaumeisterDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Nathalie HolzDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Melanie SaamDepartment of Child and Adolescent Psychiatry and Psychotherapy, University of Ulm, Ulm, Germany.
Ulrike M E SchulzeDepartment of Child and Adolescent Psychiatry and Psychotherapy, University of Ulm, Ulm, Germany.
Arjun SethiDepartment of Forensic & Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Michael CraigDepartment of Forensic & Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Josefina Castro-FornielesDepartment of Child and Adolescent Psychiatry and Psychology, Clínic Institute of Neurosciences, Hospital Clínic de Barcelona, 2017SGR881, University of Barcelona, CIBERSAM, IDIBAPS, Barcelona, Spain.
Celso ArangoChild and Adolescent Psychiatry Department, Hospital General Universitario Gregorio Marañón School of Medicine, Universidad Complutense, IiSGM, CIBERSAM, Madrid, Spain.
Susanne WalitzaDepartment of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.
Julia WerhahnDepartment of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.
Daniel BrandeisDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Barbara FrankeDepartment of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
I Hyun RuischDepartment of Child and Adolescent Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. i.h.ruisch@umcg.nl.
Jan K BuitelaarDepartment of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
Andrea Dietrich *Department of Child and Adolescent Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Pieter J Hoekstra *Department of Child and Adolescent Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Funding

Seventh Framework Programme 602805 (Aggressotype), 603016 (MATRICS)
6 · The paper itself

Abstract

While impaired response inhibition has been reported in attention-deficit/hyperactivity disorder (ADHD), findings in disruptive behavior disorders (DBDs) have been inconsistent, probably due to unaccounted effects of co-occurring ADHD in DBD. This study investigated the associations of behavioral and neural correlates of response inhibition with DBD and ADHD symptom severity, covarying for each other in a dimensional approach. Functional magnetic resonance imaging data were available for 35 children and adolescents with DBDs (8-18 years old, 19 males), and 31 age-matched unaffected controls (18 males) while performing a performance-adjusted stop-signal task. No significant association was found between behavioral performance and symptom severities. However, contrasting successful inhibition with failed inhibition revealed that DBD and ADHD symptom severity was associated with greater activation in the right inferior frontal regions and reduced activation in the bilateral striatal regions, respectively. During successful inhibition versus go-trials, ADHD symptom severity was associated with the left lateral occipital cortex activation. The contrast of failed inhibition versus go-trials revealed reduced activation in the right frontal and left parietal regions associated with DBD symptom severity while ADHD symptom severity was associated with bilateral precunei, dorsolateral prefrontal and left posterior parietal regions. Except for the right inferior frontal regions during successful versus failed inhibition, all clusters were also found to be inversely associated with the other dimension of interest (i.e., DBD or ADHD symptoms). Opposite direction of the associations between DBD and ADHD symptom severity, and fronto-parietal and fronto-striatal activation suggest unique contributions of DBD and ADHD to the neural correlates of response inhibition.

Indexed as

Attention Deficit and Disruptive Behavior DisordersAttention Deficit Disorder with HyperactivityBrainInhibition, PsychologicalAdolescentCase-Control StudiesChildFemaleHumansMagnetic Resonance ImagingMaleSeverity of Illness IndexAttention-deficit/hyperactivity disorderDimensional approachDisruptive behavior disorderFunctional magnetic resonance imagingResponse inhibition

Identifiers

PMID39825936
PMCPMC12334431

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.