A Comprehensive Review on Exploring the Potential of Phytochemicals and Biogenic Nanoparticles for the Treatment of Antimicrobial-Resistant Pathogenic Bacteria.

Antimicrobial resistance (AMR) is an escalating global health concern that results in approximately 700,000 deaths annually owing to drug-resistant infections. It compromises the effectiveness of conventional antibiotics, as well as fundamental medical procedures, such as surgery and cancer treatment. Phytochemicals, natural plant constituents, and biogenic nanoparticles synthesized through biological processes are pharmacological alternatives for supplementing or replacing traditional antibiotics. These natural compounds exhibit a diverse range of bioactive properties, including antibacterial, anti-inflammatory, and antioxidant activities, and have the potential to overcome bacterial resistance mechanisms. However, their limited solubility, bioavailability, and stability have limited their therapeutic potential. Nanotechnology, particularly the utilization of biogenic nanoparticles, offers the potential to overcome these limitations by enhancing the biosafety, stability, and controlled release of phytochemical compounds, thereby enabling a more effective combination of resistant pathogens. This review examines current research on the combinatorial application of phytochemicals and biogenic nanoparticles, with emphasis on their capacity to address AMR. This study presents a novel perspective on the concurrent utilization of phytochemicals and biogenic nanoparticles, which may enhance antibacterial efficacy while mitigating toxicity. This review provides specific and innovative insights into the novelty, sustainability, and eco-friendly aspects of these approaches to address multidrug-resistant infections, highlighting their role in emerging as a transformative strategy for AMR management through the integration of natural and biogenic resources.