ArticleOphthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)2025
Quantifying tear exchange during rigid contact lens wear using corneoscleral profilometry: A proof of concept study.
Article in Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Scleral Lens Fenestrations and Fluid Reservoir Debris.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Tear Dynamics During Fenestrated Scleral Lens Wear: A Pilot Study.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Long-term impact of scleral contact lens use on endothelial cell density in patients with moderate to advanced keratoconus.BMC ophthalmology · 2026Article
- Quantifying tear exchange during rigid contact lens wear using corneoscleral profilometry: A proof of concept study.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025Article
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Authors and funding
5 authors.
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Abstract
introductionTear exchange during contact lens wear is essential for ocular surface integrity, facilitating debris removal, and maintaining corneal metabolism. Fluorophotometry and fluorogram methods are typically used to measure tear exchange, which require hardware modifications to a slit lamp biomicroscope. This manuscript introduces an alternative method using a corneoscleral profilometer, the Eye Surface Profiler (ESP), to quantify tear exchange during corneal and scleral rigid lens wear by assessing fluorescence intensity changes over time.
methodsAs a proof of concept, a healthy participant wore a corneal and a scleral rigid lens on separate days. After lens application, 2% sodium fluorescein was instilled, and ESP images were captured at intervals over a 30-min period for corneal and a 90-min period for the scleral lens. Fluorescence intensity data were extracted and analysed using MATLAB, restricted to a region of interest centred on the contact lens. The fluorescence intensity was fitted with an exponential decay curve to quantify tear exchange.
resultsFluorescence intensity decreased over time for both lenses, with a faster decay rate being observed for the corneal lens. The scleral lens showed an initial ingress of fluorescein into the fluid reservoir, then a slow decay in fluorescence intensity due to limited tear exchange. The decay rate for the corneal lens was approximately four times faster than the scleral lens, with the time to reach 50% decay of ~42 min for the corneal lens compared to ~157 min for the scleral lens.
conclusionA new method was developed to quantify tear exchange using a commercially available corneoscleral profilometer, offering a wider field of view than existing techniques. This approach has clinical potential in scleral lens practice for identifying landing zone misalignment and improving the understanding of post-lens tear dynamics, particularly in cases involving scleral lens modifications or patients experiencing midday fogging.
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