Evidence map›Paper›PMID 39825677›Full record

SynthesisJournal of child psychology and psychiatry, and allied disciplines2025

Research Review: Sex differences in the clinical correlates of nonsuicidal self-injury in adolescents - a systematic review.

Fiona Moloney, Jasmine Amini, Mark Sinyor, Ayal Schaffer, Krista Lanctôt, Rachel H B Mitchell

Abstract readSystematic Review
In one paragraph

Synthesis in Journal of child psychology and psychiatry, and allied disciplines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Association between PMFrontiers in public health · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Fiona MoloneyDepartment of Psychiatry, University of Toronto, Toronto, ON, Canada.ORCID 0000-0002-5547-6431
Jasmine AminiDepartment of Psychiatry, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Toronto, ON, Canada.ORCID 0009-0009-4459-6735
Mark SinyorDepartment of Psychiatry, University of Toronto, Toronto, ON, Canada.ORCID 0000-0002-7756-2584
Ayal SchafferDepartment of Psychiatry, University of Toronto, Toronto, ON, Canada.ORCID 0000-0001-6220-5042
Krista LanctôtDepartment of Psychiatry, University of Toronto, Toronto, ON, Canada.ORCID 0000-0001-7024-6637
Rachel H B MitchellDepartment of Psychiatry, University of Toronto, Toronto, ON, Canada.ORCID 0000-0002-6361-0469

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNonsuicidal self-injury (NSSI), or 'the deliberate, self-inflicted destruction of body tissue…without suicidal intent and for purposes not culturally sanctioned', is a robust predictor of future suicide-related behavior and therefore a modifiable target for suicide prevention. The prevalence of NSSI is rising in adolescents, particularly among females; however, it is unknown whether sex differences also exist in the clinical and psychosocial factors associated with NSSI. Understanding how the correlates of NSSI differ by sex is important for developing tailored treatments. This study systematically reviews sex differences in the clinical and psychosocial correlates of NSSI among adolescents.

methodsMEDLINE and PsycINFO were searched using the keywords 'adolescents', 'self-injury', and 'sex factors' and synonyms for English-language articles published between January 1, 2000 and May 10, 2022. We included studies that presented original data on NSSI, included adolescents ages 10-19, reported sex differences, and explicitly defined self-injury as that done without suicidal intent. Fifty-seven studies containing 54 unique samples were included. Data were summarized by sex and recorded by: (a) characteristics of NSSI, (b) clinical and psychosocial correlates of NSSI, and (c) associations with suicide.

resultsWe used data on NSSI from 54 unique samples of adolescents worldwide. Males more commonly used violent methods of NSSI, such as burning, and were more likely to be physically aggressive and experience substance abuse. Females more commonly self-injured by cutting, and their NSSI was more likely to be repetitive and associated with emotional distress. In both sexes, NSSI was associated with adverse childhood experiences (ACEs) such as sexual abuse/violence and bullying. NSSI was predictive of suicide in females but not males.

conclusionsData from 22 countries and 352,516 participants suggest important sex differences in the clinical and psychosocial factors associated with NSSI among adolescents that future assessment and treatment strategies ought to consider.

Indexed as

Adolescent BehaviorSelf-Injurious BehaviorAdolescentChildFemaleHumansMaleSex FactorsYoung AdultadolescentNonsuicidal self‐injuryself‐harm

Identifiers

PMID39825677
PMCPMC12267678

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.