Evidence map›Paper›PMID 39825623›Full record

ArticleEpigenomics2025

DNA methylation at birth and IgE trajectories from birth to adolescence, different patterns between White and Asian.

Hongmei Zhang, Jiasong Duan, Luhang Han, Naznin Alam, Meredith Ray, Fen Yang, Yu Jiang, Susan Ewart, John W Holloway, Wilfried Karmaus and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hongmei ZhangDivision of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TN, USA.
Jiasong DuanDepartment of Statistics, University of South Carolina, Columbia, SC, USA.
Luhang HanDepartment of Preventive Medicine, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
Naznin AlamDivision of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TN, USA.
Meredith RayDivision of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TN, USA.
Fen YangDivision of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TN, USA.
Yu JiangDivision of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TN, USA.
Susan EwartDepartment of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA.
John W HollowayHuman Development & Health, Faculty of Medicine, University of Southampton, Southampton, UK, USA.
Wilfried KarmausDivision of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TN, USA.
Shu-Li WangNational Institute of Environmental Health Sciences, Taiwan.
S Hasan ArshadNIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.

Funding

Does epigenetic methylation explain the gender-switch in adolescent asthma?R01AI121226 · NIAID · UNIVERSITY OF MEMPHIS · PI HOLLOWAY, JOHN W, ZHANG, HONGMEI · 2016 to 2020
$3.2M
Effect of Prenatal Compounds on Adult Lung Function via Neonatal DNA MethylationR01HL132321 · NHLBI · UNIVERSITY OF MEMPHIS · PI KARMAUS, WILFRIED JJ · 2016 to 2020
$3.2M
Clusters of Epigenetic Networks at Birth and Asthma Incidence in ChildrenR21AI175891 · NIAID · UNIVERSITY OF MEMPHIS · PI ZHANG, HONGMEI · 2023 to 2024
$380k
NHLBI NIH HHS R01 HL132321NIAID NIH HHS R01 AI121226NIAID NIH HHS R21 AI175891
6 · The paper itself

Abstract

aimWe aim to assess association of DNA methylation (DNAm) at birth with total immunoglobulin E (IgE) trajectories from birth to late adolescence and whether such association is ethnicity-specific.

methodsWe examined the association of total IgE trajectories from birth to late adolescence with DNAm at birth in two independent birth cohorts, the Isle of wight birth cohort (IOWBC) in UK (

resultsTwo total IgE trajectories, high vs. low, were inferred from each of the two cohorts. Associations of DNAm at 103 CpGs with IgE trajectories in IOWBC and at 476 CpGs in MICS were identified. Between the two cohorts, of the identified CpGs, one was in common, methQTL site cg16711274 (mapped to gene MINAR1), and 17 pathways were common with at least four linked to airway diseases.

conclusionThe findings suggest at-birth epigenetics may explain ethnicity differences in total IgE trajectories later in life.

Indexed as

Asian PeopleDNA MethylationImmunoglobulin EWhite PeopleAdolescentChildChild, PreschoolCpG IslandsEpigenesis, GeneticFemaleHumansInfantInfant, NewbornMaleQuantitative Trait LociTaiwanImmunoglobulin EAllergyCpG sitesepigenetics at birthethnicity specificityIgE patterns

Identifiers

PMID39825623
PMCPMC11853557

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.