Evidence map›Paper›PMID 39825141›Full record

ArticleNature neuroscience2025

Dynamical constraints on neural population activity.

Emily R Oby, Alan D Degenhart, Erinn M Grigsby, Asma Motiwala, Nicole T McClain, Patrick J Marino, Byron M Yu, Aaron P Batista

Abstract read
In one paragraph

Article in Nature neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Neuromotor modules revealed by direct electrical stimulation of the human primary motor cortex.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Artificial neural manifolds.Nature communications · 2026
    Article
  4. Article
  5. Article
  6. Control of cortical population activity with patterned microstimulation.bioRxiv : the preprint server for biology · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Subspace communication in the hippocampal-retrosplenial axis.bioRxiv : the preprint server for biology · 2026
    Article
  12. Article
  13. Neural trajectories improve motor precision.bioRxiv : the preprint server for biology · 2025
    Article
  14. Article
  15. Article
  16. Motor cortex flexibly deploys a high-dimensional repertoire of subskills.bioRxiv : the preprint server for biology · 2025
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Emily R Oby *Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
Alan D Degenhart *Center for the Neural Basis of Cognition, Pittsburgh, PA, USA.
Erinn M Grigsby *Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
Asma MotiwalaCenter for the Neural Basis of Cognition, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-7693-2731
Nicole T McClainDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
Patrick J MarinoDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
Byron M YuCenter for the Neural Basis of Cognition, Pittsburgh, PA, USA. byronyu@cmu.edu.ORCID http://orcid.org/0000-0003-2252-6938
Aaron P BatistaDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA. aaron.batista@pitt.edu.ORCID http://orcid.org/0000-0002-1719-0061

Funding

Training in the Neurobiology of Neurological DiseaseT32NS086749 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Omar El Gharbawie, REBECCA P SEAL · 2014 to 2026
$4.8M
Shaping Neural Population Dynamics to Facilitate LearningR01HD071686 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BATISTA, AARON PAUL, CHASE, STEVEN M · 2011 to 2021
$3.7M
Memory Formation in Motor CortexR01NS129584 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Aaron Paul Batista, Steven M Chase · 2022 to 2026
$2.8M
Interrogating and Perturbing Neural DynamicsR01NS105318 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Aaron Paul Batista, Steven M Chase · 2017 to 2026
$2.3M
CRCNS: Modulating Neural Population Interactions between Cortical AreasR01MH118929 · NIMH · CARNEGIE-MELLON UNIVERSITY · PI SMITH, MATTHEW A, YU, BYRON M. · 2018 to 2022
$1.7M
National Science Foundation (NSF) NCS BCS1533672NICHD NIH HHS R01 HD071686NIMH NIH HHS R01 MH118929NINDS NIH HHS R01 NS105318NINDS NIH HHS R01 NS129584NINDS NIH HHS T32 NS086749U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS105318
6 · The paper itself

Abstract

The manner in which neural activity unfolds over time is thought to be central to sensory, motor and cognitive functions in the brain. Network models have long posited that the brain's computations involve time courses of activity that are shaped by the underlying network. A prediction from this view is that the activity time courses should be difficult to violate. We leveraged a brain-computer interface to challenge monkeys to violate the naturally occurring time courses of neural population activity that we observed in the motor cortex. This included challenging animals to traverse the natural time course of neural activity in a time-reversed manner. Animals were unable to violate the natural time courses of neural activity when directly challenged to do so. These results provide empirical support for the view that activity time courses observed in the brain indeed reflect the underlying network-level computational mechanisms that they are believed to implement.

Indexed as

Action PotentialsModels, NeurologicalMotor CortexNerve NetNeuronsAnimalsBrain-Computer InterfacesMacaca mulattaMaleTime Factors

Identifiers

PMID39825141
PMCPMC11802451

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.