Evidence map›Paper›PMID 39825091›Full record

ArticleCommunications biology2025

Understanding pectin cross-linking in plant cell walls.

Irabonosi Obomighie, Iain J Prentice, Peter Lewin-Jones, Fabienne Bachtiger, Nathan Ramsay, Chieko Kishi-Itakura, Martin W Goldberg, Tim J Hawkins, James E Sprittles, Heather Knight and 1 more

Abstract read
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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  9. Insights into the roles of RALF peptides and CrRLK1L receptors in fruit ripening.The Plant journal : for cell and molecular biology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Irabonosi ObomighieDepartment of Biosciences and Durham Centre for Crop Improvement Technology, Durham University, Durham, UK.ORCID http://orcid.org/0000-0002-0892-6401
Iain J PrenticeDepartment of Chemistry, University of Warwick, Coventry, UK.
Peter Lewin-JonesWarwick Mathematics Institute, University of Warwick, Coventry, UK.ORCID http://orcid.org/0000-0001-5592-1243
Fabienne BachtigerDepartment of Chemistry, University of Warwick, Coventry, UK.
Nathan RamsayDepartment of Biosciences and Durham Centre for Crop Improvement Technology, Durham University, Durham, UK.
Chieko Kishi-ItakuraDepartment of Biosciences and Durham Centre for Crop Improvement Technology, Durham University, Durham, UK.
Martin W GoldbergDepartment of Biosciences and Durham Centre for Crop Improvement Technology, Durham University, Durham, UK.
Tim J HawkinsDepartment of Biosciences and Durham Centre for Crop Improvement Technology, Durham University, Durham, UK.
James E SprittlesWarwick Mathematics Institute, University of Warwick, Coventry, UK.ORCID http://orcid.org/0000-0002-4169-6468
Heather KnightDepartment of Biosciences and Durham Centre for Crop Improvement Technology, Durham University, Durham, UK. p.h.knight@durham.ac.uk.ORCID http://orcid.org/0000-0003-2047-6084
Gabriele C SossoDepartment of Chemistry, University of Warwick, Coventry, UK. g.sosso@warwick.ac.uk.ORCID http://orcid.org/0000-0002-6156-7399

Funding

RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) BB/V015559/1, BB/M011186/1RCUK | Engineering and Physical Sciences Research Council (EPSRC) EP/S022848/1, EP/W031426/1,672 EP/S029966/1, EP/P031684/1, EP/X035603/1, EP/T022108/1
6 · The paper itself

Abstract

Pectin is a major component of plant cells walls. The extent to which pectin chains crosslink with one another determines crucial properties including cell wall strength, porosity, and the ability of small, biologically significant molecules to access the cell. Despite its importance, significant gaps remain in our comprehension, at the molecular level, of how pectin cross-links influence the mechanical and physical properties of cell walls. This study employs a multidisciplinary approach, combining molecular dynamics simulations, experimental investigations, and mathematical modelling, to elucidate the mechanism of pectin cross-linking and its effect on cell wall porosity. The computational aspects of this work challenge the prevailing egg-box model, favoring instead a zipper model for pectin cross-linking, whilst our experimental work highlights the significant impact of pectin cross-linking on cell wall porosity. This work advances our fundamental understanding of the biochemistry underpinning the structure and function of the plant cell wall. This knowledge has important implications for agricultural biotechnology, informing us about the chemical properties of plant pectins that are best suited for improving crop resilience and amenability to biofuel extraction by modifying the cell wall.

Indexed as

Cell WallPectinsPlant CellsMolecular Dynamics SimulationPectins

Identifiers

PMID39825091
PMCPMC11748717

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.