Evidence map›Paper›PMID 39825078›Full record

ArticleScientific reports2025

An In Vitro Study of the Effects of Methotrexate Loaded Biocomposite Beads on MG63 Osteoblast Cells.

A E Malash, A A Al-Esnawy, Khairy T Ereiba, Ahmed M Bakr, A S Abdraboh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

A E MalashPhysics Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, 11884, Egypt.
A A Al-EsnawyPhysics Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, 11884, Egypt. a.alesnawy@azhar.edu.eg.
Khairy T EreibaPhysics Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, 11884, Egypt.
Ahmed M BakrSpectroscopy Department, Physics Research Division, National Research Centre, 33 El Bohouth St., Dokki, Giza, 12622, Egypt.
A S AbdrabohPhysics Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, 11884, Egypt. Ah_biophysics6@azhar.edu.eg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aims to synthesize a new localized drug delivery system of bioglass, polyvinyl alcohol (PVA), cellulose (CNC), and sodium alginate (SA) beads as a carrier for methotrexate (MTX) drugs for the treatment of osteosarcoma. Methotrexate /Bioglass-loaded Polyvinyl/Cellulose/Sodium alginate biocomposite beads were prepared via the dropwise method with different concentrations of (65%SiO

Indexed as

Antimetabolites, AntineoplasticMethotrexateOsteoblastsAlginatesCell Line, TumorCell SurvivalCelluloseCeramicsDrug CarriersDrug Delivery SystemsDrug LiberationHumansMicrospheresOsteosarcomaPolyvinyl AlcoholAlginatesAntimetabolites, AntineoplasticBioglassCelluloseDrug CarriersMethotrexatePolyvinyl AlcoholBeadsBioactivityBioglassCell cultureCell lineDrug carrier

Identifiers

PMID39825078
PMCPMC11748677

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.