Evidence map›Paper›PMID 39825073›Full record

ArticleJournal of cancer research and clinical oncology2025

Immunogenic dying cells elicit potent anti-tumor T cell immunity against lung metastasis and tumorigenesis.

Jiong Deng, Min Hu, Xinyu Meng, Tong Wang, Yifan Wang, Xiaodong Chen, Dongliang Xu, Wei He, Hongjia Zhang, Wenzheng Guo and 14 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cancer research and clinical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors.

Jiong DengMedical Research Center, Binzhou Medical University Hospital, Binzhou, Shandong, 256600, P.R. China. jiongdeng@bzmc.edu.cn.
Min HuDepartment of Laboratory Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200123, China.
Xinyu MengMedical Research Center, Binzhou Medical University Hospital, Binzhou, Shandong, 256600, P.R. China.
Tong WangDepartment of Physiology, School of Basic Medical Sciences, Shandong Second Medical University, Weifang, 261021, China.
Yifan WangCancer Institute of Integrative Medicine, Zhejiang Key Laboratory of Cancer Prevention and Therapy Combining Traditional Chinese and Western Medicine, Zhejiang Academy of Traditional Chinese Medicine, Tongde Hospital of Zhejiang Province, Hangzhou, China.
Xiaodong ChenDepartment of Radiation Oncology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, 26400, Shandong, China.
Dongliang XuKey Laboratory of Cell Differentiation and Apoptosis of Chinese Minister of Education, Department of Pathophysiology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Wei HeKey Laboratory of Cell Differentiation and Apoptosis of Chinese Minister of Education, Department of Pathophysiology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Hongjia ZhangKey Laboratory of Cell Differentiation and Apoptosis of Chinese Minister of Education, Department of Pathophysiology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Wenzheng GuoDepartment of Laboratory Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200123, China.
Bo JingDepartment of Laboratory Medicine, Shanghai Pulmonary Hospital Affiliated Tongji University, Shanghai, 200080, China.
Siwei ZhangKey Laboratory of Cell Differentiation and Apoptosis of Chinese Minister of Education, Department of Pathophysiology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Jianhua XuDepartment of Laboratory Medicine, Shanghai Pulmonary Hospital Affiliated Tongji University, Shanghai, 200080, China.
Beibei SunDepartment of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, 200030, China.
Xueqian SunMedical Research Center, Binzhou Medical University Hospital, Binzhou, Shandong, 256600, P.R. China.
Tingting LiuMedical Research Center, Binzhou Medical University Hospital, Binzhou, Shandong, 256600, P.R. China.
Na NiMedical Research Center, Binzhou Medical University Hospital, Binzhou, Shandong, 256600, P.R. China.
Tongtong ZhangDepartment of Radiation Oncology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, 26400, Shandong, China.
Wenwen CuiDepartment of Physiology, School of Basic Medical Sciences, Shandong Second Medical University, Weifang, 261021, China.
Xiaoyu WuDepartment of Physiology, School of Basic Medical Sciences, Shandong Second Medical University, Weifang, 261021, China.
Liping XiaMedical Research Center, Binzhou Medical University Hospital, Binzhou, Shandong, 256600, P.R. China.
Feng YaoDepartment of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, 200030, China.
Fang ZhangDepartment of Radiation Oncology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, 26400, Shandong, China.
Jing DuMedical Research Center, Binzhou Medical University Hospital, Binzhou, Shandong, 256600, P.R. China.

Funding

Clinical Research project of Shanghai Municipal Health Commission 20214Y0247Foundation of Key Laboratory of Cancer Prevention and Therapy Combining Traditional Chinese and Western Medicine of Zhejiang Province 2022025DJKey Projects of Shandong Provincial Natural Science Foundation/Joint Fund ZR202306150012National Nature Science Foundation of China 31900441National Nature Science Foundation of China 82002941National Nature Science Foundation of China 82003069National Nature Science Foundation of China 82072570National Nature Science Foundation of China 82103571National Nature Science Foundation of China 82172565National Nature Science Foundation of China 82272408NSFSD ZR2019MC026Youth Natural Science Foundation of Shandong Province ZR2021QH295
6 · The paper itself

Abstract

purposeImmune checkpoint blockades (ICBs) are promising, however they do not fit all types of tumor, such as those lack of tumor antigens. Induction of potent anti-tumor T cell immunity is critical for cancer therapy. In this study, we investigated the efficacy of immunotherapy via the immunogenic cell death (ICD) dying tumor cells in mouse models of lung metastasis and tumorigenesis.

methodsICD was induced by short exposure to lethal dose of chemotherapeutic drug doxorubicin (Dox), which initiated an irreversible ICD program in tumor cells. We immunized mice with ICD dying tumor cells in prevention, therapy in lung metastasis models, and Gprc5a-knockout (ko) model of lung tumorigenesis. T cells and macrophages isolated from lymph nodes or tumor tissues were analyzed by flow cytometry. Cytokines were analyzed by ELISA or Q-PCR analysis.

resultsImmunization with these live but ICD dying tumor cells induced potent tumor-specific anti-tumor T cell immunity, which not only protected host from challenge by these tumor cells in prevention and therapy in mouse model of lung metastasis, but also prevented tumors development in Gprc5a-ko mouse model of lung tumorigenesis. The lymphocytes from lymph nodes and tumor tissues exhibited greatly enhanced activities of Th1 cells and M1 macrophages.

conclusionImmunization with the ICD dying tumor cells evokes potent tumor-specific T cell immunity, which provides a novel approach for cancer immunotherapy.

Indexed as

CarcinogenesisImmunogenic Cell DeathLung NeoplasmsT-LymphocytesAnimalsCell Line, TumorDoxorubicinFemaleHumansImmunotherapyMiceMice, Inbred C57BLMice, KnockoutReceptors, G-Protein-CoupledDoxorubicinReceptors, G-Protein-CoupledImmunogenic cell deathLung metastasisLung tumorigenesisT cell immunityTumor vaccine

Identifiers

PMID39825073
PMCPMC11741992

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