ArticleUpdates in surgery2025
Will the autofluorescence take over inadvertent parathyroidectomy? Results from a multicentre cohort study.
Article in Updates in surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Quantitative optimisation of indocyanine green fluorescence for parathyroid imaging in robotic BABA thyroidectomy: a prospective cohort study.Surgical endoscopy · 2026Article
- Impact of intraoperative parathyroid identification and accidental removal on post-thyroidectomy hypocalcemia: a single-center 15-year experience.BMC surgery · 2026Article
- A novel automated parathyroid glands detection and segmentation method in thyroidectomy.BMC surgery · 2026Article
- Clinical significance and risk factors of incidental parathyroidectomy after total thyroidectomy.Endocrine · 2025Article
- Propensity score-matched analysis of the '2+2' parathyroid strategy in total thyroidectomy with central neck dissection.Frontiers in endocrinology · 2025Article
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecently, several devices exploiting the near-infrared autofluorescence (NIR-AF) of parathyroid glands (PGs) have been developed. Nevertheless, their impact on both preserving PGs from inadvertent surgical dissection and on post-surgical hypoparathyroidism (hypoPTH) is controversial.
methodsA retrospective study of 845 patients undergoing thyroid surgery in 2 academic tertiary centres was conducted. In 291 patients, a NIR-AF device was used during surgery to identify PGs. The characteristics of the cohort were examined. The number of PGs identified during surgery, missed PGs, auto-transplants, inadvertent parathyroidectomies, as well as the occurrence of transient and permanent hypoPTH, were analysed.
resultsThe use of NIR-AF device resulted in a higher identification of PGs (92% versus 88%, p = 0.0008), and a significant reduction in the number of PGs inadvertently removed and detected on histopathological examination (4.7% versus 6.5%, p = 0.045). An increase in PG auto-transplantations was observed in the NIR-AF + group (10.4% versus 3.5%, p < 0.0001). The use of NIRAF did not significantly impact the occurrence of either transient or permanent hypoPTH.
conclusionIntraoperative NIR-AF detection is a promising technology to reduce incidental parathyroidectomies in thyroid surgery. The impact of this technology on the occurrence of post-surgical hypoPTH needs to be furtherly investigated.
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