Evidence map›Paper›PMID 39824919›Full record

ArticleNature metabolism2025

Mechanosensation of the heart and gut elicits hypometabolism and vigilance in mice.

Karen A Scott, Yalun Tan, Dominique N Johnson, Khalid Elsaafien, Caitlin Baumer-Harrison, Rebeca Méndez-Hernández, Matthew K Kirchner, Sophia A Eikenberry, Jessica M Sa, Javier E Stern and 3 more

Abstract read
In one paragraph

Article in Nature metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. The critical role of gut-brain signalling in eating behaviour and obesity.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. The gut and heart's role in reward processing.Frontiers in integrative neuroscience · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Karen A Scott *Neuroscience Institute, College of Arts and Sciences, Georgia State University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-4133-423X
Yalun Tan *Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, USA.
Dominique N JohnsonNeuroscience Institute, College of Arts and Sciences, Georgia State University, Atlanta, GA, USA.
Khalid ElsaafienNeuroscience Institute, College of Arts and Sciences, Georgia State University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0001-9581-918X
Caitlin Baumer-HarrisonDepartment of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL, USA.
Rebeca Méndez-HernándezMonell Chemical Senses Center, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-4393-3401
Matthew K KirchnerNeuroscience Institute, College of Arts and Sciences, Georgia State University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0001-6960-7685
Sophia A EikenberryDepartment of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL, USA.ORCID http://orcid.org/0000-0002-4753-5120
Jessica M SaNeuroscience Institute, College of Arts and Sciences, Georgia State University, Atlanta, GA, USA.
Javier E SternNeuroscience Institute, College of Arts and Sciences, Georgia State University, Atlanta, GA, USA.
Guillaume de LartigueMonell Chemical Senses Center, Philadelphia, PA, USA. gdelartigue@monell.org.ORCID http://orcid.org/0000-0002-0032-8810
Annette D de KloetNeuroscience Institute, College of Arts and Sciences, Georgia State University, Atlanta, GA, USA. adekloet@gsu.edu.ORCID http://orcid.org/0000-0002-7213-6957
Eric G KrauseNeuroscience Institute, College of Arts and Sciences, Georgia State University, Atlanta, GA, USA. ekrause@gsu.edu.ORCID http://orcid.org/0000-0002-2718-3113

Funding

Interrogating stress-relieving neural circuits to alleviate cardiovascular diseaseR35HL150750 · NHLBI · UNIVERSITY OF FLORIDA · PI Eric Gerald Krause · 2020 to 2026
$5.9M
Neurons expressing angiotensin type 2 receptors in the NTS as an access point for cardiovascular control.R01HL136595 · NHLBI · UNIVERSITY OF FLORIDA · PI COLIN SUMNERS, Annette Diane de Kloet · 2018 to 2026
$4.8M
Evaluating the therapeutic potential of vagal CART circuitry for treating metabolic diseaseR01DK116004 · NIDDK · UNIVERSITY OF FLORIDA · PI Guillaume FH de Lartigue · 2018 to 2026
$3.6M
Interrogating distinct angiotensin type-1 and type-2 receptor containing brain circuits to understand and alleviate hypertensionR01HL145028 · NHLBI · UNIVERSITY OF FLORIDA · PI DE KLOET, ANNETTE DIANE · 2019 to 2023
$1.9M
Blunted mechanosensation of the heart and gut as a mediator of pathogenesis conferred by chronic social subjugationR01AT013166 · NCCIH · GEORGIA STATE UNIVERSITY · PI Eric Gerald Krause, Annette Diane de Kloet · 2025 to 2026
$1.4M
Leveraging vagal oxytocin receptors to understand cardiometabolic interoceptionR56AT012142 · NCCIH · UNIVERSITY OF FLORIDA · PI DE KLOET, ANNETTE DIANE, DE LARTIGUE, GUILLAUME FH · 2022 to 2022
$588k
Investigating Afferent Baroreflex Dysfunction in HypertensionK99HL175100 · NHLBI · GEORGIA STATE UNIVERSITY · PI EL SAAFIEN, KHALID · 2024 to 2024
$136k
American Heart Association (American Heart Association, Inc.) 23POST1020034NCCIH NIH HHS R01 AT013166NCCIH NIH HHS R56 AT012142NHLBI NIH HHS K99 HL175100NHLBI NIH HHS R01 HL136595NHLBI NIH HHS R01 HL145028NHLBI NIH HHS R35 HL150750NIDDK NIH HHS R01 DK116004U.S. Department of Health & Human Services | NIH | National Center for Complementary and Integrative Health (NCCIH) AT012142U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL145028U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL150750
6 · The paper itself

Abstract

Interoception broadly refers to awareness of one's internal milieu. Although the importance of the body-to-brain communication that underlies interoception is implicit, the vagal afferent signalling and corresponding brain circuits that shape perception of the viscera are not entirely clear. Here, we use mice to parse neural circuits subserving interoception of the heart and gut. We determine that vagal sensory neurons expressing the oxytocin receptor (Oxtr), referred to as NG

Indexed as

ArousalGastrointestinal TractHeartMechanotransduction, CellularAnimalsEatingEnergy MetabolismInteroceptionMaleMiceMice, Inbred C57BLReceptors, OxytocinVagus NerveReceptors, Oxytocin

Identifiers

PMID39824919
PMCPMC12232619

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.