Evidence map›Paper›PMID 39824860›Full record

ArticleNature communications2025

Cola beverage reduces risk of lead poisoning from accidental ingestion of contaminated soil particles in rat and swine models.

Xiaoyun Xu, Quan Qian, Yao Shi, Wenfeng Huang, Chengpeng Yuan, Lena Q Ma, Willie G Harris, Jiayin Dai, Deyi Hou, Xinde Cao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiaoyun Xu *School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai, China.
Quan Qian *School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai, China.
Yao ShiSchool of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai, China.
Wenfeng HuangSchool of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai, China.
Chengpeng YuanSchool of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai, China.
Lena Q MaCollege of Environmental and Resource Sciences, Zhejiang University, Hangzhou, China.
Willie G HarrisSoil and Water Sciences Department, University of Florida, Gainesville, USA.
Jiayin DaiSchool of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai, China. daijy65@sjtu.edu.cn.
Deyi HouSchool of Environment, Tsinghua University, Beijing, China.ORCID http://orcid.org/0000-0002-0511-5806
Xinde CaoSchool of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai, China. xdcao@sjtu.edu.cn.ORCID http://orcid.org/0000-0002-2315-4219

Funding

National Natural Science Foundation of China (National Science Foundation of China) 21377081National Natural Science Foundation of China (National Science Foundation of China) 42077112National Natural Science Foundation of China (National Science Foundation of China) 42330706Science and Technology Commission of Shanghai Municipality (Shanghai Municipal Science and Technology Commission) 23QA1405200
6 · The paper itself

Abstract

Accidental ingestion of lead (Pb)-contaminated soils represents a major route of Pb exposure for both adults and children, and the development of accessible and cost-effective solutions to reduce Pb poisoning is urgently required. Here, we present an effective and straightforward technique, involving the consumption of cola beverages, for the purpose of lowering blood Pb levels following the ingestion of contaminated soils in animal models. This method facilitated the direct passage of Pb in contaminated soil through the digestive system, enhancing its elimination without absorption into systemic circulation. Our results demonstrated that cola effectively reduced Pb bioaccessibility in 22 contaminated soils by 32.6%-98.8%. In male rats and swine exposed to Pb-contaminated soils, cola treatment decreased blood Pb concentrations by 32.9%-96.0% and 31.5%-81.5%, respectively. This cola-induced reduction in Pb bioaccessibility and bioavailability was attributed to the rich phosphoric acid content in cola, which promoted the formation of insoluble Pb phosphate precipitate (pyromorphite [Pb

Indexed as

Carbonated BeveragesLeadLead PoisoningSoil PollutantsAnimalsBiological AvailabilityDisease Models, AnimalFemaleMaleRatsRats, Sprague-DawleySoilSwineLeadSoilSoil Pollutants

Identifiers

PMID39824860
PMCPMC11742081

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.