Evidence map›Paper›PMID 39824856›Full record

ArticleScientific reports2025

Neurobehavioral plasticity in the rodent gustatory system induced by regular consumption of a low-calorie sweetener during adolescence.

Clare M Mathes, Sarah J Terrill, Juan P Taborda-Bejarano, Sandrine Chometton, Mallory J Witt, Gaurikka Mendiratta, Emily G Gilman, Delenn R Hartswick, Bo M Anderson, Lindsey A Schier

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Clare M MathesDepartment of Neuroscience, Baldwin Wallace University, Berea, OH, USA.
Sarah J TerrillDepartment of Neuroscience, Carthage College, Kenosha, WI, USA.
Juan P Taborda-BejaranoDepartment of Neuroscience, Baldwin Wallace University, Berea, OH, USA.
Sandrine ChomettonDepartment of Biological Sciences, University of Southern California, 3616 Trousdale Parkway, AHF 252, Los Angeles, CA, 90089-0372, USA.
Mallory J WittDepartment of Neuroscience, Baldwin Wallace University, Berea, OH, USA.
Gaurikka MendirattaDepartment of Neuroscience, Baldwin Wallace University, Berea, OH, USA.
Emily G GilmanDepartment of Neuroscience, Baldwin Wallace University, Berea, OH, USA.
Delenn R HartswickDepartment of Neuroscience, Baldwin Wallace University, Berea, OH, USA.
Bo M AndersonDepartment of Neuroscience, Carthage College, Kenosha, WI, USA.
Lindsey A SchierDepartment of Biological Sciences, University of Southern California, 3616 Trousdale Parkway, AHF 252, Los Angeles, CA, 90089-0372, USA. Lschier@usc.edu.

Funding

Roles for Glucosensors in Taste FunctionR01DC018562 · NIDCD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SCHIER, LINDSEY A · 2021 to 2025
$2.5M
NIDCD NIH HHS R01 DC018562NIH HHS DC018562
6 · The paper itself

Abstract

Habitual consumption of low-calorie sweeteners (LCS) during juvenile-adolescence can lead to greater sugar intake later in life. Here, we investigated if exposure to the LCS Acesulfame Potassium (Ace-K) during this critical period of development reprograms the taste system in a way that would alter hedonic responding for common dietary compounds. Results revealed that early-life LCS intake not only enhanced the avidity for a caloric sugar (fructose) when rats were in a state of caloric need, it increased acceptance of a bitterant (quinine) in Ace-K-exposed rats tested when middle-aged. These behavior shifts, which endured months after the end of Ace-K exposure, were accompanied by widespread changes in the peripheral taste system. The anterior tongue had fewer fungiform taste papillae, and the circumvallate papillae had a reduced anterior to posterior span and diminished expression of genes involved in sweet reception, sweet and bitter intracellular signaling, fructose transport, and cellular progeneration in the Ace-K-exposed rats. Ace-K exposure also led to a significant reduction in dopamine-producing cells of the ventral tegmental area. The collective findings reveal that LCS intake early in life alters the taste-brain axis and the behavioral responsiveness to both positive and negative tastants that are important determinants of dietary preferences.

Indexed as

Neuronal PlasticitySweetening AgentsTasteThiazinesAnimalsBehavior, AnimalEnergy IntakeFructoseMaleRatsTaste BudsVentral Tegmental AreaacetosulfameFructoseSweetening AgentsThiazines

Identifiers

PMID39824856
PMCPMC11742420

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.