Evidence map›Paper›PMID 39824833›Full record

ArticleNature communications2025

Preference for and resistance to a toxic sulfur volatile opens up a unique niche in Drosophila busckii.

Venkatesh Pal Mahadevan, Diego Galagovsky, Markus Knaden, Bill S Hansson

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. A roadmap to key traits of invasive Drosophilidae.Biological reviews of the Cambridge Philosophical Society · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Venkatesh Pal MahadevanDepartment of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Jena, Germany.ORCID http://orcid.org/0000-0002-1437-704X
Diego GalagovskyDepartment of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Jena, Germany.ORCID http://orcid.org/0000-0003-1906-6854
Markus KnadenDepartment of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Jena, Germany.ORCID http://orcid.org/0000-0002-6710-1071
Bill S HanssonDepartment of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Jena, Germany. hansson@ice.mpg.de.ORCID http://orcid.org/0000-0002-4811-1223

Funding

Max-Planck-Gesellschaft (Max Planck Society) 000
6 · The paper itself

Abstract

The ability to tolerate otherwise toxic compounds can open up unique niches in nature. Among drosophilid flies, few examples of such adaptations are known and those which are known are typically from highly host-specific species. Here we show that the human commensal species Drosophila busckii uses dimethyldisulfide (DMDS) as a key mediator in its host selection. Despite DMDS's neurotoxic properties, D. busckii has evolved tolerance towards high concentrations and uses the compound as an olfactory cue to pinpoint food and oviposition sites. This adaptability is likely linked to insensitivity of the enzyme complex cytochrome c oxidase (COX), which is a DMDS target in other insects. Our findings position D. busckii as a potential model for studying resistance to toxic gases affecting COX and offers insight into evolutionary adaptations within specific ecological contexts.

Indexed as

DisulfidesDrosophilaSulfidesAdaptation, PhysiologicalAnimalsElectron Transport Complex IVFemaleMaleOvipositiondimethyl sulfideDisulfidesElectron Transport Complex IVSulfides

Identifiers

PMID39824833
PMCPMC11742422

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.