Evidence map›Paper›PMID 39824511›Full record

ArticleACS chemical biology2025

Novel Quinazoline Derivatives Inhibit Splicing of Fungal Group II Introns.

Olga Fedorova, Michelle Luo, G Erik Jagdmann, Michael C Van Zandt, Luke Sisto, Anna Marie Pyle

Abstract read
In one paragraph

Article in ACS chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The Viruses ofViruses · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Olga FedorovaHoward Hughes Medical Institute, Chevy Chase, Maryland 20815, United States.
Michelle LuoDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.
G Erik JagdmannNew England Discovery Partners, Branford, Connecticut 06405, United States.
Michael C Van ZandtNew England Discovery Partners, Branford, Connecticut 06405, United States.ORCID 0000-0002-9624-5699
Luke SistoDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, United States.
Anna Marie PyleHoward Hughes Medical Institute, Chevy Chase, Maryland 20815, United States.ORCID 0000-0001-9045-8872

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report the discovery of small molecules that target the RNA tertiary structure of self-splicing group II introns and display potent antifungal activity against yeasts, including the major public health threat

Indexed as

Antifungal AgentsIntronsQuinazolinesRNA SplicingCandida parapsilosisHigh-Throughput Screening AssaysHumansMicrobial Sensitivity TestsRNA, FungalStructure-Activity RelationshipAntifungal AgentsQuinazolinesRNA, Fungal

Identifiers

PMID39824511
PMCPMC11851433

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.