ArticleJournal of the American Academy of Child and Adolescent Psychiatry2025
Understanding the Etiology of Externalizing Problems in Young Children: The Roles of Callous-Unemotional Traits and Irritability.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Heterogeneity of early-onset conduct problems: assessing different profiles, predictors and outcomes across childhood.Child and adolescent psychiatry and mental health · 2025Article
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5 authors.
Funding
Abstract
objectiveCallous-unemotional traits (CU), characterized as a lack of guilt and empathy, and irritability, a tendency to show anger and frustration, are 2 risk factors for externalizing behavioral problems. Externalizing problems, CU, and irritability are all heritable. However, there is a dearth of studies examining the genetic and environmental associations between the 3 domains. The present study partitioned joint and independent etiological pathways from CU and irritability to externalizing problems.
methodThe sample consisted of 614 pairs of 3-year-old twins from the Boston University Twin Project. Primary caregivers reported twins' externalizing problems, CU, and irritability using the Child Behavior Checklist. Biometric Cholesky models were used to estimate common and unique genetic and environmental variances among the 3 domains.
resultsThere were common genetic, shared environmental and nonshared environmental factors operating across all 3 domains. In addition, there were unique genetic and nonshared environmental factors, independent of the common effects, linking externalizing problems and CU, and externalizing problems and irritability, respectively. There were also genetic and nonshared environmental influences unique to externalizing problems, independent of CU and irritability.
conclusionCommon genetic as well as shared and nonshared environmental associations among externalizing problems, CU, and irritability suggest, to some extent, that etiological influences are common to all 3 constructs. However, distinct genetic and child-specific nonshared environmental links separately from CU and irritability to externalizing problems, reveals the heterogeneity of externalizing problems, and suggests that they should not be considered a unitary outcome. PLAIN LANGUAGE SUMMARY: This study examined 614 pairs of 3-year-old twins from the Boston University Twin Project to explore common and unique genetic and environmental links between externalizing problems, callous-unemotional traits, and irritability. The authors found that genetic and environmental influences were shared across behaviors. There were also unique genetic and child-specific environmental factors that separately linked callous-unemotional traits and irritability to externalizing problems. These findings increase our understanding of the etiology of externalizing problems in preschoolers and have the potential to inform early interventions. STUDY PREREGISTRATION INFORMATION: Study Preregistration: Understanding the Etiology of Externalizing Problems in Young Children: The Roles of Callous-Unemotional Traits and Irritability; https://doi.org/10.1016/j.jaac.2023.09.549.
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