Evidence map›Paper›PMID 39824380›Full record

ArticleContemporary clinical trials2025

Optimizing a mobile just-in-time adaptive intervention (JITAI) for weight loss in young adults: Rationale and design of the AGILE factorial randomized trial.

Brooke T Nezami, Carmina G Valle, Heather M Wasser, Lex Hurley, Karen E Hatley, Deborah F Tate

Abstract readClinical Trial Protocol
In one paragraph

Article in Contemporary clinical trials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Brooke T NezamiDepartment of Nutrition, Gillings School of Global Public Health and School of Medicine, University of North Carolina at Chapel Hill, 135 Dauer Drive, 245 Rosenau Hall, CB # 7461, Chapel Hill, NC 27599, USA. Electronic address: bnezami@unc.edu.
Carmina G ValleDepartment of Nutrition, Gillings School of Global Public Health and School of Medicine, University of North Carolina at Chapel Hill, 135 Dauer Drive, 245 Rosenau Hall, CB # 7461, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, 450 West Drive, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Heather M WasserDepartment of Nutrition, Gillings School of Global Public Health and School of Medicine, University of North Carolina at Chapel Hill, 135 Dauer Drive, 245 Rosenau Hall, CB # 7461, Chapel Hill, NC 27599, USA.
Lex HurleyDepartment of Health Behavior, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, 135 Dauer Drive, 170 Rosenau Hall, CB #7400, Chapel Hill, NC 27599, USA.
Karen E HatleyLineberger Comprehensive Cancer Center, 450 West Drive, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Deborah F TateDepartment of Nutrition, Gillings School of Global Public Health and School of Medicine, University of North Carolina at Chapel Hill, 135 Dauer Drive, 245 Rosenau Hall, CB # 7461, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, 450 West Drive, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Health Behavior, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, 135 Dauer Drive, 170 Rosenau Hall, CB #7400, Chapel Hill, NC 27599, USA; Nutrition Research Institute, North Carolina Research Campus, 500 Laureate Way, Kannapolis, NC 28081, USA.

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
Re-Entry Supplement: Investigation of Oral Microbial Enzymes for the Detection and Treatment of Periodontal DiseaseUL1TR002489 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, SHAHEEN, NICHOLAS J · 2018 to 2022
$48.6M
North Carolina Translational & Clinical Sciences Institute (NC TraCS)UL1TR001111 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, CAREY, TIMOTHY S · 2013 to 2017
$43.9M
North Carolina Translational and Clinical Sciences Institute (NC TraCS)UM1TR004406 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NICHOLAS J SHAHEEN · 2023 to 2026
$37.5M
UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SUSAN M. SMITH · 1999 to 2026
$31.6M
Cancer Health Disparities Training ProgramT32CA128582 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SMITH, JENNIFER SUSAN, TATE, DEBORAH F. · 2009 to 2023
$3.4M
Optimization of a mHealth Behavioral Weight Loss Intervention for Young AdultsR01DK125779 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TATE, DEBORAH F. · 2020 to 2024
$3.2M
Leveraging behavior change, social support and mHealth to advance early life obesity prevention-Adminstrative SupplementK01DK111793 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WASSER, HEATHER · 2017 to 2021
$826k
NCATS NIH HHS UL1 TR001111NCATS NIH HHS UL1 TR002489NCATS NIH HHS UM1 TR004406NCI NIH HHS P30 CA016086NCI NIH HHS T32 CA128582NIDDK NIH HHS K01 DK111793NIDDK NIH HHS P30 DK056350NIDDK NIH HHS R01 DK125779
6 · The paper itself

Abstract

backgroundYoung adults (YAs) are underrepresented in behavioral health and weight loss interventions and express interest in flexible, highly tailored programs. Mobile interventions are a lower-burden, scalable approach to providing behavioral support. Just-in-time-adaptive interventions (JITAI) promise to deliver the "right" support at the "right" time using real-time data from smartphones and sensors. JITAIs hold promise for promoting behavior changes needed for weight loss (dietary intake, activity, and self-weighing); however, there is limited evidence for selecting treatment components and levels of adaptation that are needed for success.

methodsThe AGILE (Adaptive Goals and Interventions for Lifestyle Enhancement) trial utilizes the Multiphase Optimization Strategy (MOST) framework and a 2

conclusionsResults of this trial will be used to create an optimized JITAI for weight loss in young adults.

Indexed as

Mobile ApplicationsObesityWeight Reduction ProgramsAdolescentAdultBehavior TherapyExerciseFemaleHumansMaleRandomized Controlled Trials as TopicResearch DesignSmartphoneWeight LossYoung AdultAdaptive interventionsInterventionMobileObesityOverweightWeight managementYoung adults

Identifiers

PMID39824380
PMCPMC11905495

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.