Evidence map›Paper›PMID 39824379›Full record

Trial reportContemporary clinical trials2025

A randomized controlled trial to assess whether a telehealth-based contingency management intervention reduces alcohol use for individuals with alcohol use disorder.

Julianne D Jett, Diana Tyutyunnyk, Rachael Beck, Katharine Palmer, Danielle Ryan, Jesus Sanchez, Douglas L Weeks, Sterling M McPherson, Naomi Chaytor, Brian Kiluk and 5 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Contemporary clinical trials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Julianne D JettDepartment of Community and Behavioral Health, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA. Electronic address: julianne.jett@wsu.edu.
Diana TyutyunnykDepartment of Community and Behavioral Health, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA.
Rachael BeckDepartment of Community and Behavioral Health, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA.
Katharine PalmerDepartment of Community and Behavioral Health, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA.
Danielle RyanDepartment of Population Health Sciences, Weill Cornell Medicine, New York, NY, USA.
Jesus SanchezDepartment of Psychiatry and Behavioral Sciences, University of Texas Health San Antonio, TX, USA.
Douglas L WeeksDepartment of Community and Behavioral Health, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA.
Sterling M McPhersonDepartment of Community and Behavioral Health, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA.
Naomi ChaytorDepartment of Community and Behavioral Health, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA.
Brian KilukDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Martin A JavorsDepartment of Psychiatry and Behavioral Sciences, University of Texas Health San Antonio, TX, USA.
Brett C GinsburgDepartment of Psychiatry and Behavioral Sciences, University of Texas Health San Antonio, TX, USA.
Sean MurphyDepartment of Population Health Sciences, Weill Cornell Medicine, New York, NY, USA.
Nathalie Hill-KapturczakDepartment of Psychiatry and Behavioral Sciences, University of Texas Health San Antonio, TX, USA.
Michael G McDonellDepartment of Community and Behavioral Health, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA.

Funding

Assessing the Clinical and Cost-Effectiveness of a Virtual PEth-based Contingency Management for Adults with AUDR01AA031013 · NIAAA · WASHINGTON STATE UNIVERSITY · PI Nathalie Hill-Kapturczak, Michael G McDonell · 2023 to 2026
$2.8M
Peth-Based Contingency Management to Reduce Alcohol Use and Improve Housing OutcomesR21AA027045 · NIAAA · WASHINGTON STATE UNIVERSITY · PI MCDONELL, MICHAEL G · 2019 to 2020
$397k
NIAAA NIH HHS R01 AA031013NIAAA NIH HHS R21 AA027045
6 · The paper itself

Abstract

backgroundContingency management (CM) is an intervention for alcohol use disorder (AUD) that reinforces abstinence, as confirmed by alcohol biomarkers. CM is usually brief (12-16 weeks) despite evidence that longer interventions have better long-term outcomes. Most CM models are in-person which can also be a barrier for treatment. Studies of longer duration telehealth-based CM models are needed.

aimsTo determine if a telehealth-based CM model that utilizes phosphatidylethanol (PEth) to confirm abstinence is effective at reducing alcohol use during a 26-week intervention and 12-month follow-up. We will evaluate the impact of CM on alcohol-related outcomes, determine if Addiction Neuroclinical Assessment variables are associated with outcomes in follow-up, and whether savings related to decreased alcohol use offset intervention costs.

methodsAdults with AUD residing in the United States will be recruited via online advertising. Research procedures will be conducted virtually. Participants who submit a PEth-positive blood sample (≥20 ng/mL) at enrollment will be randomized to 26 weeks of either 1) online cognitive behavior therapy (CBT4CBT) with rewards not contingent on PEth results (Control group) or 2) CBT4CBT with a maximum of $1,820 of rewards contingent on PEth results (CM group). Efficacy outcomes of PEth-negative tests (primary) and PEth-defined excessive drinking (≥200 ng/mL; secondary) will be assessed. Predictors of intervention outcomes and economic viability will also be investigated. DISCUSSION: If this telehealth-delivered PEth-based CM intervention reduces alcohol use and is cost-effective, it could be used to provide effective treatment to millions of individuals with AUD who do not receive in-person care.

Indexed as

Alcohol AbstinenceAlcohol DrinkingAlcoholismCognitive Behavioral TherapyAdultBiomarkersFemaleGlycerophospholipidsHumansMaleRewardTelemedicineUnited StatesBiomarkersGlycerophospholipidsphosphatidylethanolAddictions neuroclinical assessment frameworkAlcohol use disorder (AUD)Contingency management (CM)Phosphatidylethanol (PEth)TelehealthUrine ethyl glucuronide (uEtG)

Identifiers

PMID39824379
PMCPMC12261975

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.