Evidence map›Paper›PMID 39824188›Full record

ArticleStem cell reports2025

Transplantation of genome-edited retinal organoids restores some fundamental physiological functions coordinated with severely degenerated host retinas.

Mikiya Watanabe, Takayuki Yamada, Chieko Koike, Masayo Takahashi, Masao Tachibana, Michiko Mandai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mikiya WatanabeVCCT Inc., Kobe, Hyogo 650-0047, Japan; Graduate School of Pharmacy, Ritsumeikan University, Kusatsu, Siga 525-8577, Japan; Cell and Gene Therapy in Ophthalmology Laboratory, BZP, RIKEN, Wako, Saitama 351-0198, Japan.
Takayuki YamadaCell and Gene Therapy in Ophthalmology Laboratory, BZP, RIKEN, Wako, Saitama 351-0198, Japan; Vision Care Inc., Kobe, Hyogo 650-0047, Japan.
Chieko KoikeCenter for Systems Vision Science, Organization of Science and Technology, Ritsumeikan University, Kusatsu, Shiga 525-8577, Japan; Ritsumeikan Global Innovation Research Organization(R-GIRO), Ritsumeikan University, Kusatsu, Siga 525-8577, Japan; College of Pharmaceutical Science, Ritsumeikan University, Kusatsu, Siga 525-8577, Japan.
Masayo TakahashiVision Care Inc., Kobe, Hyogo 650-0047, Japan; Ritsumeikan Advanced Research Academy, Ritsumeikan University, Kusatsu, Shiga 525-8577, Japan.
Masao TachibanaCenter for Systems Vision Science, Organization of Science and Technology, Ritsumeikan University, Kusatsu, Shiga 525-8577, Japan.
Michiko MandaiResearch Center, Kobe City Eye Hospital, Kobe, Hyogo 650-0047, Japan; Research Organization of Science and Technology, Ritsumeikan University, Kusatsu, Shiga 525-8577, Japan; Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Biosystems Dynamics Research, Kobe, Hyogo 650-0047, Japan. Electronic address: e_lab.mandai@kcho.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have previously shown that the transplantation of stem cell-derived retinal organoid (RO) sheets into animal models of end-stage retinal degeneration can lead to host-graft synaptic connectivity and restoration of vision, which was further improved using genome-edited Islet1

Indexed as

Gene EditingOrganoidsRetinaRetinal DegenerationAnimalsDisease Models, AnimalMiceRetinal Ganglion CellselectrophysiologyES cellmulti-electrode arraysorganoidphotoreceptor cell degenerationretinaretinal organoid sheetstem celltransplantationvisual function

Identifiers

PMID39824188
PMCPMC11864131

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.