Evidence map›Paper›PMID 39824008›Full record

ArticleNuclear medicine and biology

Characterization of a novel PET radioligand for mitochondrial complex I in nonhuman primate.

Yulong Xu, Yiming Xu, Frederick Andrew Bagdasarian, Tewodros Mulugeta Dagnew, Hua Cheng, Yanli Wang, Yongle Wang, Leyi Kang, Hsiao-Ying Wey, Can Zhang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nuclear medicine and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yulong XuAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, United States.
Yiming XuDepartment of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA 23298, United States.
Frederick Andrew BagdasarianAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, United States.
Tewodros Mulugeta DagnewAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, United States.
Hua ChengAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, United States.
Yanli WangAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, United States.
Yongle WangAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, United States.
Leyi KangAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, United States.
Hsiao-Ying WeyAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, United States.
Can ZhangGenetics and Aging Research Unit, McCance Center for Brain Health, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, United States.
Shijun ZhangDepartment of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA 23298, United States. Electronic address: szhang2@vcu.edu.
Changning WangAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, United States. Electronic address: cwang15@mgh.harvard.edu.

Funding

Project 4P41EB015896 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2012 to 2018
$9.8M
Development of novel NLRP3 inflammasome inhibitors for intervening in Alzheimer's diseaseU01AG076481 · NIA · VIRGINIA COMMONWEALTH UNIVERSITY · PI Shijun Zhang · 2022 to 2026
$7.5M
Probing neuroinflammation in Alzheimer's disease with NLRP3 PET radiotracersRF1AG076912 · NIA · VIRGINIA COMMONWEALTH UNIVERSITY · PI ZHANG, SHIJUN · 2023 to 2023
$1.9M
NIA NIH HHS RF1 AG076912NIA NIH HHS U01 AG076481NIBIB NIH HHS P41 EB015896
6 · The paper itself

Abstract

The role of mitochondrial complex I (MC-I) dysfunction is well-documented across a range of neurodegenerative disorders. Recently, a novel positron emission tomography (PET) radioligand, [

Indexed as

Electron Transport Complex IMitochondriaPositron-Emission TomographyAnimalsBrainFluorine RadioisotopesLigandsMacaca mulattaMaleRadiochemistryTissue DistributionElectron Transport Complex IFluorine RadioisotopesLigandsBrain tissueMitochondrial complex IPositron emission tomographyRadiotracersRhesus macaque

Identifiers

PMID39824008
PMCPMC12048266

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.