Evidence map›Paper›PMID 39823681›Full record

Trial reportThe journal of nutrition, health & aging2025

Daily Supplementation with Protein-Enriched Lacto-Vegetarian Soups and Muscle Health in Community-Dwelling Older Adults: A Randomized Controlled Trial.

Sheng-Lun Kao, Jen-Hung Wang, Hsi-Yu Lai, Fei-Yuan Hsiao, Liang-Kung Chen, Ching-Hui Loh

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The journal of nutrition, health & aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. What Is 'Muscle Health'? A Narrative Review and Conceptual Framework.Journal of functional morphology and kinesiology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sheng-Lun KaoDepartment of Family Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan; Department of Family Medicine, College of Medicine, Tzu Chi University, Hualien, Taiwan.
Jen-Hung WangDepartment of Medical Research, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Hsi-Yu LaiGraduate Institute of Clinical Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan.
Fei-Yuan HsiaoGraduate Institute of Clinical Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan; School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Pharmacy, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: fyshsiao@ntu.edu.tw.
Liang-Kung ChenCenter for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan; Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan; Taipei Municipal Gan-Dau Hospital, Taipei, Taiwan. Electronic address: lkchen2@vghtpe.gov.tw.
Ching-Hui LohDepartment of Family Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan; Department of Family Medicine, College of Medicine, Tzu Chi University, Hualien, Taiwan; Center for Healthy Longevity, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan. Electronic address: twdoc1960@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDietary protein adequacy is crucial for muscle health in aging individuals, posing a particular challenge for vegetarian seniors. This randomized controlled trial (RCT) investigates the impacts of protein-enriched lacto-vegetarian soup supplementation on body composition, physical performance and muscle strength functional assessment as well as cardiometabolic and inflammatory biomarkers in older adults.

methodsWe enrolled 100 participants ≥65 years at risk for malnutrition (MNA-SF ≤ 11) and at risk for sarcopenia (SARC-F ≥4 or SARC-CalF ≥11) in this RCT. Participants were randomized assigned to receive a daily protein-enriched lacto-vegetarian soup (24-30 g protein) or usual diet. Primary outcomes of interest including (1) body composition (anthropometric measurements and body composition measured by bioimpedance analysis (BIA)), (2) physical performance (Short Physical Performance Battery, SPPB) and muscle strength (hand grip strength), and (3) functional assessments (including sarcopenia risk scales and nutritional status) as well as secondary outcomes of interests including cardiometabolic and inflammatory biomarkers were assessed at baseline and the 12th week of follow-up.

resultsData of 97 participants (intervention: n = 48, control: n = 49) were analyzed. Despite no significant changes in body composition were observed in the intervention group, compared to the usual diet, those who received protein-enriched lacto-vegetarian soup supplementation had an improved physical performance including an increase in SPPB score (β = 0.83 [95% CI 0.15-1.51], p = 0.02), a decrease in time to complete the 5 times chair rise test (β = -2.25 [-4.04 to -0.44], p = 0.01). Some functional assessments, including improved sarcopenia risk scale (e.g., SARC-F score [β = -0.68, p = 0.04]) and nutritional status (e.g., MNA-SF score [β = 0.44, p = 0.03]) were also observed.

conclusionsDaily supplementation with protein-enriched lacto-vegetarian soups enhanced physical performance and functional assessments (such as sarcopenia risk scale and nutritional status) among older adults at risk of malnutrition and sarcopenia. Further study is needed to explore the long-term benefits of protein-enriched lacto-vegetarian soup supplementation for healthy aging.

Indexed as

Dietary ProteinsDietary SupplementsSarcopeniaAgedAged, 80 and overBiomarkersBody CompositionFemaleGeriatric AssessmentHand StrengthHumansIndependent LivingMaleMalnutritionMuscle StrengthNutritional StatusBiomarkersDietary ProteinsCardiometabolic riskDietary proteinsInflammatory biomarkersLacto-vegetarianMalnutritionOlder adultsPhysical performanceRandomized controlled trialsSarcopenia

Identifiers

PMID39823681
PMCPMC12180063

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.