Evidence map›Paper›PMID 39823557›Full record

ReviewJournal of clinical oncology : official journal of the American Society of Clinical Oncology2025

Clonal Hematopoiesis in Women With Breast Cancer.

Christina Mayerhofer, Rachel A Freedman, Heather A Parsons, Ann H Partridge, Peter G Miller

Abstract readReview
In one paragraph

Review in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Risk factors of clonal hematopoiesis of indeterminate potential.Clinical medicine (London, England) · 2026
    Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Christina MayerhoferDepartment of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Cambridge, MA.ORCID 0000-0002-5755-1458
Rachel A FreedmanHarvard Medical School, Boston, MA.ORCID 0000-0003-0460-674X
Heather A ParsonsBroad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA.ORCID 0000-0001-8178-6612
Ann H PartridgeHarvard Medical School, Boston, MA.ORCID 0000-0002-4722-4824
Peter G MillerBroad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA.ORCID 0000-0002-6797-9335

Funding

Can a subset of patients with HER2+ metastatic breast cancer be cured?K08CA252639 · NCI · FRED HUTCHINSON CANCER CENTER · PI PARSONS, HEATHER ANNE · 2021 to 2025
$1.3M
Role of PPM1D and PPM1D mutations in hematopoiesis and response to stressK08CA263183 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI MILLER, PETER GRANT · 2021 to 2025
$1.1M
NCI NIH HHS K08 CA252639NCI NIH HHS K08 CA263183
6 · The paper itself

Abstract

purposeClonal hematopoiesis (CH) has been associated with a variety of adverse outcomes, most notably hematologic malignancy and ischemic cardiovascular disease. A series of recent studies also suggest that CH may play a role in the outcomes of patients with solid tumors, including breast cancer. Here, we review the clinical and biological data that underlie potential connections between CH, inflammation, and breast cancer, with a focus on the prevalence and impact of clonal hematopoiesis of indeterminate potential in patients with breast cancer.

methodsWe summarize data from multiple studies, including a series of cohorts of patients with breast cancer, to assess the prevalence of CH, the relationship between CH and exposure to cytotoxic therapy, and the correlation between CH and breast cancer-specific outcomes.

resultsOur findings indicate that CH is prevalent among patients with breast cancer, particularly those treated with cytotoxic therapies. However, there are no definitive data to support an association between the presence of CH and breast cancer-specific outcomes.

conclusionCurrent data do not support routine CH testing in patients with breast cancer, nor should the presence of CH influence decisions regarding breast cancer therapy in most patients. However, larger, long-term studies are necessary to further define the implications of CH in patients with breast cancer and guide clinical decision making.

Indexed as

Breast NeoplasmsClonal HematopoiesisFemaleHumans

Identifiers

PMID39823557
PMCPMC11867839

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.