Evidence map›Paper›PMID 39823472›Full record

SynthesisPloS one2025

Effects of antioxidant nutrients on muscle mass, strength and function in COPD patients: A meta-analysis of randomized controlled trials.

Qinman He, Pan Yang, Ye Wang, Wanmei Xu, Yi Feng, Fei Xie, Guixiang Xu

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qinman HeDepartment of Respiratory and Critical Care Medicine, First Affiliated Hospital of Army Medical University, Chongqing, P. R. China.ORCID 0009-0005-5420-8653
Pan YangDepartment of Respiratory and Critical Care Medicine, First Affiliated Hospital of Army Medical University, Chongqing, P. R. China.
Ye WangDepartment of Respiratory and Critical Care Medicine, First Affiliated Hospital of Army Medical University, Chongqing, P. R. China.
Wanmei XuDepartment of Respiratory and Critical Care Medicine, First Affiliated Hospital of Army Medical University, Chongqing, P. R. China.
Yi FengDepartment of Respiratory and Critical Care Medicine, First Affiliated Hospital of Army Medical University, Chongqing, P. R. China.
Fei XieDepartment of Respiratory and Critical Care Medicine, First Affiliated Hospital of Army Medical University, Chongqing, P. R. China.
Guixiang XuDepartment of Respiratory and Critical Care Medicine, First Affiliated Hospital of Army Medical University, Chongqing, P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo comprehensively investigate the effects of antioxidant nutrients on muscle mass, strength and function in chronic obstructive pulmonary disease (COPD) patients.

methodsPubMed, Embase, Cochrane Library, and Web of Science were comprehensively searched from the inception to January 3, 2024. The quality of randomized controlled trials (RCTs) was measured using the Jadad scale. Weighted mean differences (WMDs) and 95% confidence intervals (CIs) were used as the effect size for measurement data. Further, subgroup analysis was conducted based on whether patients participated in lung rehabilitation plans while receiving nutritional interventions. Sensitivity analysis was performed on all outcomes.

resultsA total of 12 studies involving 595 patients with COPD were included, with 11 studies had high quality, and one study had low quality. For muscle mass, patients receiving antioxidant nutrients had a significantly increased lean body mass index compared with those not receiving antioxidant nutrients (pooled WMD: 0.903, 95% CI: 0.264, 1.541, P = 0.006). For patients who did not participate in lung rehabilitation plan while receiving nutritional interventions, antioxidant nutrients brought about a significantly higher lean body mass index (pooled WMD: 1.360, 95% CI: 0.560, 2.160, P = 0.001). For muscle strength, patients in the antioxidant nutrient intervention group had significantly higher hand grip strength (HGS) than those in the non-antioxidant nutrient intervention group (pooled WMD: 1.976, 95% CI: 1.337, 2.615, P < 0.001). Patients receiving antioxidant nutrients had significantly greater inspiratory muscle strength (MIP) than those not receiving antioxidant nutrients (pooled WMD: 8.127, 95% CI: 2.677, 13.577, P = 0.003).

conclusionAntioxidant nutrient intervention significantly improved HGS, MIP and lean body mass index in COPD. Clinicians should consider increasing food intake or supplementation rich in antioxidants in the treatment plan of patients with COPD.

Indexed as

AntioxidantsMuscle, SkeletalMuscle StrengthNutrientsPulmonary Disease, Chronic ObstructiveBody Mass IndexHand StrengthHumansMaleRandomized Controlled Trials as TopicAntioxidantsNutrients

Identifiers

PMID39823472
PMCPMC11741611

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.