Evidence map›Paper›PMID 39823430›Full record

ArticlePloS one2025

Automating the amino acid identification in elliptical dichroism spectrometer with Machine Learning.

Ridhanya Sree Balamurugan, Yusuf Asad, Tommy Gao, Dharmakeerthi Nawarathna, Umamaheswara Rao Tida, Dali Sun

Abstract read
In one paragraph

Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ridhanya Sree BalamuruganElectrical and Computer Engineering, North Dakota State University, Fargo, North Dakota, United States of America.
Yusuf AsadElectrical and Computer Engineering, North Dakota State University, Fargo, North Dakota, United States of America.
Tommy GaoElectrical and Computer Engineering, University of Denver, Denver, Colorado, United States of America.ORCID 0009-0005-3132-7860
Dharmakeerthi NawarathnaElectrical and Computer Engineering, Old Dominion University, Norfolk, Virginia, United States of America.
Umamaheswara Rao TidaElectrical and Computer Engineering, North Dakota State University, Fargo, North Dakota, United States of America.ORCID 0000-0002-9724-1585
Dali SunElectrical and Computer Engineering, University of Denver, Denver, Colorado, United States of America.

Funding

Tracking and Evaluation CoreU54GM128729 · NIGMS · UNIVERSITY OF NORTH DAKOTA · PI BASSON, MARC D. · 2018 to 2022
$20.3M
Exosomal Contents Guided Amino Acids Treatment for Pancreatic CancerR21CA270748 · NCI · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI SUN, DALI · 2022 to 2023
$369k
Using the secondary structure (beta-sheet) of exosomal proteins for noninvasive pancreatic cancer detectionR03CA252783 · NCI · NORTH DAKOTA STATE UNIVERSITY · PI SUN, DALI · 2020 to 2020
$145k
NCI NIH HHS R03 CA252783NCI NIH HHS R21 CA270748NIGMS NIH HHS U54 GM128729
6 · The paper itself

Abstract

Amino acid identification is crucial across various scientific disciplines, including biochemistry, pharmaceutical research, and medical diagnostics. However, traditional methods such as mass spectrometry require extensive sample preparation and are time-consuming, complex and costly. Therefore, this study presents a pioneering Machine Learning (ML) approach for automatic amino acid identification by utilizing the unique absorption profiles from an Elliptical Dichroism (ED) spectrometer. Advanced data preprocessing techniques and ML algorithms to learn patterns from the absorption profiles that distinguish different amino acids were investigated to prove the feasibility of this approach. The results show that ML can potentially revolutionize the amino acid analysis and detection paradigm.

Indexed as

Amino AcidsCircular DichroismMachine LearningAlgorithmsAmino Acids

Identifiers

PMID39823430
PMCPMC11741379

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.