Evidence map›Paper›PMID 39823338›Full record

ArticleScience advances2025

Control of striatal circuit development by the chromatin regulator

Kyuhyun Choi, Nathan T Henderson, Emily R Feierman, Sean Louzon, Jamie Galanaugh, Felicia Davatolhagh, Isha Bhandaru, David J Tischfield, Stewart A Anderson, Erica Korb and 1 more

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kyuhyun ChoiDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0003-0605-2437
Nathan T HendersonDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-9285-6687
Emily R FeiermanNeuroscience Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-2133-5825
Sean LouzonDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Jamie GalanaughDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-9358-7928
Felicia DavatolhaghDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-0607-5164
Isha BhandaruDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0009-0005-7798-2692
David J TischfieldDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Stewart A AndersonDepartment of Psychiatry, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.ORCID 0000-0002-7655-5016
Erica KorbDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-7064-8123
Marc V FuccilloDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-6569-706X

Funding

A Novel Role for Local Striatal Interneuron Regulation of Goal-Directed ActionR01MH118369 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI FUCCILLO, MARC V · 2020 to 2024
$2.8M
The epigenetic encoding of learning and memoryDP2MH129985 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI KORB, ERICA MEGAN · 2021 to 2024
$2.4M
NIMH NIH HHS DP2 MH129985NIMH NIH HHS R01 MH118369
6 · The paper itself

Abstract

The pathophysiology of neurodevelopmental disorders involves vulnerable neural populations, including striatal circuitry, and convergent molecular nodes, including chromatin regulation and synapse function. Despite this, how epigenetic regulation regulates striatal development is understudied. Recurrent de novo mutations in

Indexed as

ChromatinCorpus StriatumAnimalsEpigenesis, GeneticMiceNeuronsReceptors, AMPASynapsesSynaptic TransmissionChromatinReceptors, AMPA

Identifiers

PMID39823338
PMCPMC11740973

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.