Evidence map›Paper›PMID 39823332›Full record

ArticleScience advances2025

Morphogenesis of bacterial cables in polymeric environments.

Sebastian Gonzalez La Corte, Corey A Stevens, Gerardo Cárcamo-Oyarce, Katharina Ribbeck, Ned S Wingreen, Sujit S Datta

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Morphogenesis of bacterial colonies in liquid crystalline environments.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Article
  4. Selective Trapping of Bacteria in Porous Media by Cell Length.Integrative and comparative biology · 2026
    Article
  5. Article
  6. Spatial self-organization of confined bacterial suspensions.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Form and function in biological filaments: a physicist's review.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025
    Review
  8. Dissecting the physics of bacterial biofilms with agent-based simulations.Current opinion in solid state & materials science · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Sebastian Gonzalez La CorteLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.ORCID 0000-0003-1607-5632
Corey A StevensDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Gerardo Cárcamo-OyarceDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0001-8324-6900
Katharina RibbeckDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0001-8260-338X
Ned S WingreenDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA.ORCID 0000-0001-7384-2821
Sujit S DattaDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID 0000-0003-2400-1561

Funding

Thermally robust chemotaxis and thermotaxis in Escherichia coliR01GM082938 · NIGMS · PRINCETON UNIVERSITY · PI WINGREEN, NED S · 2008 to 2025
$5.5M
NIGMS NIH HHS R01 GM082938
6 · The paper itself

Abstract

Many bacteria live in polymeric fluids, such as mucus, environmental polysaccharides, and extracellular polymers in biofilms. However, laboratory studies typically focus on cells in polymer-free fluids. Here, we show that interactions with polymers shape a fundamental feature of bacterial life-how they proliferate in space in multicellular colonies. Using experiments, we find that when polymer is sufficiently concentrated, cells generically and reversibly form large serpentine "cables" as they proliferate. By combining experiments with biophysical theory and simulations, we demonstrate that this distinctive form of colony morphogenesis arises from an interplay between polymer-induced entropic attraction between neighboring cells and their hindered ability to diffusely separate from each other in a viscous polymer solution. Our work thus reveals a pivotal role of polymers in sculpting proliferating bacterial colonies, with implications for how they interact with hosts and with the natural environment, and uncovers quantitative principles governing colony morphogenesis in such complex environments.

Indexed as

BacteriaBiofilmsMorphogenesisPolymersModels, BiologicalPolymers

Identifiers

PMID39823332
PMCPMC11740958

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.