Evidence map›Paper›PMID 39823318›Full record

ReviewScience immunology2025

Architects of immunity: How dendritic cells shape CD8

Vidit Bhandarkar, Teresa Dinter, Stefani Spranger

Abstract readReview
In one paragraph

Review in Science immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. CD8Cell reports. Medicine · 2026
    Review
  7. Renaissance of antiviral CD8Nature reviews. Immunology · 2026
    Review
  8. Mechanisms, Microenvironments, and Models: Understanding Therapeutic Resistance in Glioblastoma.International journal of radiation oncology, biology, physics · 2026
    Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Vidit BhandarkarKoch Institute at MIT, Cambridge, MA 02139, USA.ORCID 0000-0002-6526-4360
Teresa DinterKoch Institute at MIT, Cambridge, MA 02139, USA.ORCID 0000-0003-4764-501X
Stefani SprangerKoch Institute at MIT, Cambridge, MA 02139, USA.ORCID 0000-0003-3257-4546

Funding

VIRUS PRODUCTION COREP30CA014051 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Jacqueline A. Lees · 1985 to 2026
$93.9M
TRAINING GRANTS IN ENVIROMENTAL TOXICOLOGYT32ES007020 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ESSIGMANN, JOHN M · 1985 to 2024
$13.1M
Understanding the induction of T cell dysfunction in the context of lung cancerR37CA273819 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Stefani Spranger · 2023 to 2026
$1.9M
NCI NIH HHS P30 CA014051NCI NIH HHS R37 CA273819NIEHS NIH HHS T32 ES007020
6 · The paper itself

Abstract

Immune responses against cancer are dominated by T cell exhaustion and dysfunction. Recent advances have underscored the critical role of early priming interactions in establishing T cell fates. In this review, we explore the importance of dendritic cell (DC) signals in specifying CD8

Indexed as

CD8-Positive T-LymphocytesDendritic CellsNeoplasmsAnimalsCancer VaccinesHumansCancer Vaccines

Identifiers

PMID39823318
PMCPMC11970844

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.