Evidence map›Paper›PMID 39823301›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

An evolutionarily conserved cation channel tunes the sensitivity of gustatory neurons to ephaptic inhibition in

MinHyuk Lee, Seon Yeong Kim, Taeim Park, Sung-Eun Yoon, Young-Joon Kim, Kyeung Min Joo, Jae Young Kwon, Kyuhyung Kim, KyeongJin Kang

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Emerging tools to advance neuroethology in butterflies and moths.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

MinHyuk LeeNeurovascular Unit Research Group, Korea Brain Research Institute, Daegu 41062, Republic of Korea.ORCID 0009-0007-6101-5053
Seon Yeong KimNeurovascular Unit Research Group, Korea Brain Research Institute, Daegu 41062, Republic of Korea.ORCID 0009-0008-9383-7876
Taeim ParkNeurovascular Unit Research Group, Korea Brain Research Institute, Daegu 41062, Republic of Korea.
Sung-Eun YoonSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.ORCID 0000-0002-9162-2352
Young-Joon KimSchool of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.ORCID 0000-0002-7990-754X
Kyeung Min JooDepartment of Anatomy and Cell Biology, Sungkyunkwan University School of Medicine, Samsung Biomedical Research Institute, Samsung Medical Center, Suwon 16419, Republic of Korea.
Jae Young KwonDepartment of Biological Sciences, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Kyuhyung KimDepartment of Brain Sciences, Daegu Gyeongbuk Institute of Science & Technology (DGIST), Daegu 42988, Republic of Korea.ORCID 0000-0002-9943-5092
KyeongJin KangNeurovascular Unit Research Group, Korea Brain Research Institute, Daegu 41062, Republic of Korea.ORCID 0000-0003-0446-469X

Funding

Korea Brain Research Institute (KBRI) 23-BR-01-02 22-BR-03-06Korea Brain Research Institute (KBRI) 24-BR-02-15National Research Foundation of Korea (NRF) 2021R1A2B5B01002702National Research Foundation of Korea (NRF) 2021R1A2C1008418National Research Foundation of Korea (NRF) 2022M3E5E8017946
6 · The paper itself

Abstract

In ephaptic coupling, physically adjacent neurons influence one another's activity via the electric fields they generate. To date, the molecular mechanisms that mediate and modulate ephaptic coupling's effects remain poorly understood. Here, we show that the hyperpolarization-activated cyclic nucleotide-gated (HCN) channel lateralizes the potentially mutual ephaptic inhibition between

Indexed as

Drosophila melanogasterDrosophila ProteinsHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsNeuronsTasteAnimalsDrosophilaHumansReceptors, Cell SurfaceSensillaDrosophila Proteinsgustatory receptor, DrosophilaHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsReceptors, Cell SurfaceDrosophilaephaptic couplinghyperpolarization-induced inward currentsweetness dominancetaste interaction

Identifiers

PMID39823301
PMCPMC11760501

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.