Evidence map›Paper›PMID 39823300›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Stimulating the regenerative capacity of the human retina with proneural transcription factors in 3D cultures.

Juliette Wohlschlegel, Faith Kierney, Kayla L Arakelian, Guillaume Luxardi, Naran Suvarnpradip, Dawn Hoffer, Fred Rieke, Ala Moshiri, Thomas A Reh

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Stimulating the regenerative capacity of the human retina with proneural transcription factors in 3D cultures.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Juliette WohlschlegelDepartment of Biological Structure, University of Washington, Seattle, WA 98125.ORCID 0000-0003-4317-9066
Faith KierneyDepartment of Biological Structure, University of Washington, Seattle, WA 98125.
Kayla L ArakelianDepartment of Biological Structure, University of Washington, Seattle, WA 98125.
Guillaume LuxardiDepartment of Ophthalmology & Vision Science, University of California Davis School of Medicine, Sacramento, CA 95616.ORCID 0000-0003-3338-0583
Naran SuvarnpradipDepartment of Ophthalmology & Vision Science, University of California Davis School of Medicine, Sacramento, CA 95616.
Dawn HofferDepartment of Biological Structure, University of Washington, Seattle, WA 98125.
Fred RiekeDepartment of Physiology and Biophysics, University of Washington, Seattle, WA 98125.
Ala MoshiriDepartment of Ophthalmology & Vision Science, University of California Davis School of Medicine, Sacramento, CA 95616.
Thomas A RehDepartment of Biological Structure, University of Washington, Seattle, WA 98125.ORCID 0000-0002-3524-0886

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Sakeneh Zraika · 1986 to 2026
$41.4M
Intravitreal gene therapy for inherited retinal diseaseR01EY034123 · NEI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ALA MOSHIRI · 2023 to 2026
$2.7M
Foundation Fighting Blindness (FFB) TA-RM-0620-0788-UWANEI NIH HHS R01 EY034123NIDDK NIH HHS P30 DK017047Tenpoint Biotherapeutics no specific #
6 · The paper itself

Abstract

Retinal diseases often lead to degeneration of specific retinal cell types with currently limited therapeutic options to replace the lost neurons. Previous studies have reported that overexpression of

Indexed as

RegenerationRetinaTranscription FactorsAdultAnimalsBasic Helix-Loop-Helix ProteinsCells, CulturedEpendymoglial CellsHumansMiceNeurogenesisRegenerative MedicineASCL1 protein, humanBasic Helix-Loop-Helix ProteinsTranscription Factorsglianeurogenesisregenerationreprogrammingretina

Identifiers

PMID39823300
PMCPMC11759899

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.