ArticleChemSusChem2025
Mechanochemistry: Unravelling the Impact of Metal Leaching in Organic Synthesis.
Article in ChemSusChem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Mechanochemistry Meets Catalysis: Metal Complexes for Greener Organic Transformations.Angewandte Chemie (International ed. in English) · 2026Review
- Mechanochemical Methods for Amide Bond Formation.Chemical reviews · 2026Review
- Safe and Sustainable by Design (SSbD) Synthesis of Food and Personal Care Ingredients by Mechanochemistry.ChemSusChem · 2026Article
- Beyond Simple Grinding: Methylammonium Chloride Promotes Sustainable, Cylinder-Free Mechanochemical Synthesis of Deferiprone.ChemSusChem · 2025Article
- Solid-State Photochemistry in Resonant Acoustic Mixers.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Thermally accelerated Heck reaction under direct mechanocatalysis using palladium milling balls.RSC mechanochemistry · 2025Article
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Solvent-free techniques have gained considerable attention in recent years due to their environmental advantages and potential to enable chemical reactivities beyond the reach of traditional solution-based methods. Mechanochemistry has emerged as a groundbreaking approach to drive sustainable chemical processes. Despite its promise, some challenges still need to be explored, including the overlooked issue of material leaching during grinding, a phenomenon in which components from milling media or reaction vessels, such as stainless steel, unintentionally alter reaction outcomes. This study investigates the role of metal leaching in reducing arylnitrosamines by using a poorly soluble solid reagent, thiourea dioxide (TDO), focusing on stainless steel vessels. By comparing conventional mechanochemical methods with innovative solvent-free vibratory techniques, we assess the extent of metal contamination and its impact on reaction efficiency. These findings provide new insights into how material leaching influences chemical processes and offer valuable guidance for optimizing these forward-looking and green methodologies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.