Evidence map›Paper›PMID 39823170›Full record

Trial reportAging cell2025

Characterization of Human Senescent Cell Biomarkers for Clinical Trials.

Joshua N Farr, David G Monroe, Elizabeth J Atkinson, Mitchell N Froemming, Ming Ruan, Nathan K LeBrasseur, Sundeep Khosla

Abstract readClinical Trial, Phase IIRandomized Controlled Trial
In one paragraph

Trial report in Aging cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Integrating senotherapeutics into transplantation: liver reconditioning in an aging donor pool.Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Senotherapeutics for Brain Aging Management.Neurology international · 2025
    Review
  13. Article
  14. Article
  15. Functional Features of Senescent Cells and Implications for Therapy.International journal of molecular sciences · 2025
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Joshua N FarrDivision of Endocrinology, Mayo Clinic, Rochester, Minnesota, USA.
David G MonroeDivision of Endocrinology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-4818-0114
Elizabeth J AtkinsonDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA.
Mitchell N FroemmingDivision of Endocrinology, Mayo Clinic, Rochester, Minnesota, USA.
Ming RuanDivision of Endocrinology, Mayo Clinic, Rochester, Minnesota, USA.
Nathan K LeBrasseurRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-2002-0418
Sundeep KhoslaDivision of Endocrinology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-2936-4372

Funding

Targeting Cellular Senescence to Extend HealthspanP01AG062413 · NIA · MAYO CLINIC ROCHESTER · PI Nathan K LeBrasseur · 2019 to 2026
$28.7M
Defining the interactions of senescent immune cells and skeletal cellsR01AG076515 · NIA · MAYO CLINIC ROCHESTER · PI Sundeep Khosla, David G Monroe · 2022 to 2026
$2.4M
Targeting Cellular Senescence and RAGE in Type 2 DiabetesR01DK128552 · NIDDK · UNIVERSITY OF ARIZONA · PI FARR, JOSHUA NICHOLAS · 2021 to 2025
$2.0M
Characterization of senescent cell populations in skeletal agingR01AG086085 · NIA · MAYO CLINIC ROCHESTER · PI Sundeep Khosla, David G Monroe · 2024 to 2026
$1.6M
The Role of Cellular Senescence in Mediating Age-Related Bone LossK01AR070241 · NIAMS · MAYO CLINIC ROCHESTER · PI FARR, JOSHUA NICHOLAS · 2016 to 2020
$640k
Targeting cellular senescence with senolytics to improve skeletal health in older humansR21AG065868 · NIA · MAYO CLINIC ROCHESTER · PI FARR, JOSHUA NICHOLAS, KHOSLA, SUNDEEP · 2020 to 2021
$419k
Hevolution HR-GRO-23-1199144-8NIAMS NIH HHS K01 AR070241NIA NIH HHS P01 AG062413NIA NIH HHS R01 AG076515NIA NIH HHS R01 AG086085NIA NIH HHS R21 AG065868NIDDK NIH HHS R01 DK128552
6 · The paper itself

Abstract

There is an increasing need for biomarkers of senescent cell burden to facilitate the selection of participants for clinical trials. p16

Indexed as

BiomarkersCellular SenescenceClinical Trials as TopicAgedCyclin-Dependent Kinase Inhibitor p16DasatinibFemaleHumansMiddle AgedQuercetinBiomarkersCyclin-Dependent Kinase Inhibitor p16DasatinibQuercetinbiomarkersp16SASPsenescence

Identifiers

PMID39823170
PMCPMC12073900

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.