ArticleTranslational pediatrics2024
Anesthetics change the oral microbial composition of children and increase the abundance of the genus
Article in Translational pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Oral microbiome homeostasis is important for children's health, and microbial community is affected by anesthetics. The application of anesthetics in children's oral therapy has become a relatively mature method. This study aims to investigate the effect of different anesthesia techniques on children's oral microbiota. Methods: Sixty children who visited the Department of Stomatology of the Jiangxi Provincial Children's Hospital were recruited. Subjects who did not receive anesthesia during the surgery were divided into non-anesthesia (Noa) group. Other children who accepted anesthesia during the surgery were grouped into lidocaine group, sevoflurane group, and intravenous injection-inhalation (intra-inhalation) group. Subsequently, their saliva samples were collected for 16S rDNA sequencing. Results: A total of 1,316 operational taxonomic units (OTUs) were identified in overall samples, and 75,275 reads per sample were obtained on average. There were 137 genera were shared among the Noa, lidocaine, sevoflurane, and intra-inhalation groups. The genera Conclusions: This study elucidated oral microbiome characteristics in children under different anesthesia technology and found an enrichment of
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