ArticleAsian journal of transfusion science
Prevalence of hemoglobinopathies using high-performance liquid chromatography as diagnostic tool in anemic patients of tertiary care center of Western India.
Article in Asian journal of transfusion science. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Screening for beta thalassemia trait in a heterogeneous university-based population in Delhi-NCR, India.Journal of community genetics · 2026Article
- Article
- Stroke From Paradoxical Embolism in a Young Patient With Sickle-Cell Disease and High Fetal Hemoglobin: A Diagnostic Challenge.Clinical case reports · 2026Article
- High-Resolution Genetic Profiling of Hb J-Meerut and Other Hemoglobin Variants in the Tharu Population via HPLC and DNA Sequencing.Diagnostics (Basel, Switzerland) · 2025Article
- Distribution of Hemoglobinopathy Disorders in Al-Kharj Province Based on Data from the Premarital Screening and Genetic Counseling Program.Medicina (Kaunas, Lithuania) · 2025Article
- Ocular Biometric Findings in Thalassemia Major: A Systematic Review and Meta-Analysis.Journal of current ophthalmologyReview
- Epidemiological Profile of Haemoglobinopathies in Different Districts of West Bengal: A Retrospective Study.Nigerian medical journal : journal of the Nigeria Medical AssociationArticle
- Prevalence and assessment of the impact of iron-deficiency anemia in beta-thalassemia trait subjects: A study from a tertiary care center of Western India.Asian journal of transfusion scienceArticle
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5 authors.
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Abstract
contextHemoglobinopathies are the most common heterogeneous group of monogenetic disorder in the world and its prevalence varies with geographical regions. India is developing country and many studies show a significant burden of hemoglobinopathies in India.
aimsThe aim of the present study was to check the prevalence of various hemoglobinopathies in anemic subjects using high-performance liquid chromatography (HPLC) method in Pune region which has multiple ethnic population groups from all parts of India. SETTINGS AND
designThe present study was conducted at the department of IH and BT on anemic patients referred from different outpatient department and Wards of the hospital and informed consent were taken from all participants. SUBJECTS AND
methodsThe present study included a total of 2698 individuals' age ranging from 1.5 to 67 years. The HPLC test was performed using Bio-Rad D-10 analyzer once a week.
resultsOut of a total of 2698 cases, we found 543 (20.12%) cases with abnormal hemoglobin fractions and 2155 (79.88%) cases free from hemoglobinopathies. Out of the total hemoglobinopathies detected 250 (46%) were male and 293 (54%) were female. The major abnormality detected was beta-thalassemia trait (BTT) with 425 (15.75%) cases, followed by sickle cell disorders 58 (2.15%), HbE 38 (1.41%), hereditary persistence of fetal hemoglobin 6 (0.22%), HbD Punjab 13 (0.48%), HbD Iran 2 cases and 4 cases of compound heterozygous for HbS beta-thalassemia. Forty (1.48%) cases were detected as borderline with HbA2 level ranges from 3.6% to 3.9%.
conclusionsIn our study, we found a high prevalence of hemoglobinopathies among anemic subjects. The most common disorder detected was BTT. Most of the hemoglobinopathies found in our study could be accurately quantified by HPLC which is a rapid, sensitive, and reproducible method for the detection of different hemoglobinopathies.
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