ArticleNeurophotonics2025
Seizure network characterization by functional connectivity mapping and manipulation.
Article in Neurophotonics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Simultaneous mesoscopic imaging of neural activity and hemodynamics reveals anesthetic modulation of neurovascular responses.Photoacoustics · 2026Article
- Piriform seizures mediated by the piriform-entorhino-dentate circuit induce brain-wide functional reorganization in mice.PLoS biology · 2026Article
- Introduction to the Special Issue "Understanding Brain Disease with Live Imaging".Neurophotonics · 2025Article
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Authors and funding
9 authors.
Funding
Abstract
Significance: Despite the availability of various anti-seizure medications, nearly 1/3 of epilepsy patients experience drug-resistant seizures. These patients are left with invasive surgical options that do not guarantee seizure remission. The development of novel treatment options depends on elucidating the complex biology of seizures and brain networks. Aim: We aimed to develop an experimental paradigm that uses anatomical network information, functional connectivity, and Approach: Guided by a known anatomical network, we applied widefield calcium imaging to determine how neural activity and seizures spread through the network regions, focusing on the primary somatosensory cortex and secondary motor cortex. We used Results: The microstimulation of the somatosensory cortex propagated in a distinct pattern throughout the bilateral network with sequential reproducible node recruitment. Seizures recapitulated this same pattern, indicating a hijacking of existing pathways. Ablation of a key node in the network in the secondary motor cortex changed contralateral spread. Early chronic cobalt seizure data are presented. Conclusion: Here, we demonstrate a paradigm for combining widefield calcium imaging with microstimulation, cortical ablation, and seizure mapping to determine how anatomical networks inform the propagation patterns of cortical seizures. These experiments can be extended to long-term tracking of epilepsy to study epileptogenesis in other cortical networks. Our proof-of-concept findings suggest that this paradigm may be useful in the development of novel therapies for drug-resistant epilepsy patients and can be extended to the study of other disorders involving brain networks.
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Registered trials
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