ReviewRSC advances2025
Multicomponent reactions (MCRs) yielding medicinally relevant rings: a recent update and chemical space analysis of the scaffolds.
Review in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- A deep eutectic solvent mediated synthesis of spiro[naphthalene-2,5'-pyrimidine]-4-carbonitriles and theirRSC advances · 2026Article
- Access to Cyclic Monensin Derivatives via a Four-Component Ugi Reaction.The Journal of organic chemistry · 2026Article
- Multicomponent reactions for protein tyrosine phosphatase inhibitors.Molecular diversity · 2026Review
- Multicomponent Hosomi-Sakurai Reaction on Isosorbide Derivatives.Molecules (Basel, Switzerland) · 2026Article
- Nanoparticle-Catalysed Microwave-Driven MCRs for Sustainable Heterocycle Synthesis.Molecules (Basel, Switzerland) · 2026Review
- Rational design and synthesis of non-competitive transcription inhibitors targeting a conserved RNA polymerase-σRSC advances · 2026Article
- A Three-Layer Transformation Strategy toward Functionalized Fused Hydantoins and Diketopiperazines.Organic letters · 2026Article
- A green fabrication of pharmacologically relevant fused pyrimidines using recyclable caffeine-HRSC advances · 2026Article
- RHA/TiOScientific reports · 2026Article
- AgRSC advances · 2026Article
- Photocatalyzed hydrogen atom transfer enables multicomponent olefin oxo-amidomethylation under aerobic conditions.Chemical science · 2025Article
- One-Pot Four-Component Synthesis of Novel Amino-Tetrahydro-Chromene Derivatives Anchored with Dual Triazole Moieties.ChemistryOpen · 2025Article
- Article
- Biochar: a robust and renewable basic carbocatalyst for sustainable synthesis of diversified spirooxindoles.RSC advances · 2025Article
- Photocatalysis Enables Chemodivergent Radical Polar Crossover: Ritter-Type Amidation vs Heck-Type Olefin Carbofunctionalizations.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- A multicomponent reaction-initiated synthesis of imidazopyridine-fused isoquinolinones.Beilstein journal of organic chemistry · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this review we have compiled multicomponent reactions (MCRs) that produce cyclic structures. We have covered articles reported since 2019 to showcase the recent advances in this area. In contrast to other available reviews on this topic, we focus specifically on MCRs with strong prospects in medicinal chemistry. Consequently, the reactions operating in a single-pot and yielding novel rings or new substitution patterns under mild conditions are highlighted. Moreover, MCRs that do not require special reagents or catalysts and yield diverse products from commercially available building blocks are reviewed. The synthetic schemes, substrate scope, and other key aspects such as regio- and stereoselectivity are discussed for each MCR. Using cheminformatic tools, we have also attempted to characterize the chemical space of the scaffolds obtained from these MCRs. We show that the MCR scaffolds are novel, more complex, and globular in shape compared to the approved drugs and clinical candidates. Thus, our review represents a step towards identifying and characterizing the novel ring space that can be accessed efficiently through MCRs in a short timeframe.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.