ReviewAmerican journal of translational research2024
Scoliosis in adult Type 1 Chiari malformation with syringomyelia patients: from pathogenesis to treatment.
Review in American journal of translational research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pathogenesis of type I Chiari malformation (CIM) is complex and remains unclear. The theory of posterior cranial fossa incompatibility has gained widespread acceptance in recent years. In the patients with CIM combined with syringomyelia, scoliosis is a common occurrence, with severe cases often leading to complications that necessitate surgical intervention. Scoliosis of various etiologies manifests as a three-dimensional structural spinal deformity. The etiology of scoliosis secondary to Chiari malformation is well-defined, and its imaging characteristics resemble those of idiopathic scoliosis. Vertebral rotation plays a critical role in the onset and progression of the deformity. However, spinal orthopaedic surgery in these patients is more challenging and hazardous due to the Chiari malformation and associated spinal cord abnormalities. Accurate preoperative assessment of scoliosis, Chiari malformation, and syringomyelia (SM), along with strategic planning of surgical approaches and fusion segment selection, is essential for improving patient outcomes and prognosis. In adults, CIM presents with more severe clinical manifestations compared to children, mainly including brainstem and cranial nerve compression, spinal-related syndromes, cerebellar injury syndromes, and hydrocephalus. Consequently, scoliosis deformities are often overlooked. Currently, there are limited reports on the efficacy of spinal correction surgery in adult patients with scoliosis associated with adult Type 1 Chiari malformation with syringomyelia (CIM-SM). Additionally, it remains uncertain whether and when syringomyelia should be addressed in these patients. This study aims to review previous research and explore whether intervention for Chiari malformation and syringomyelia should precede spinal orthopaedic surgery, as well as to evaluate the efficacy of spinal correction procedures.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.